Dopamine receptors: from structure to function
Abstract
The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase. The other receptor subtypes belong to the D2-like subfamily (D2, D3, and D4) and are prototypic of G protein-coupled receptors that inhibit adenylyl cyclase and activate K+ channels. The genes for the D1 and D5 receptors are intronless, but pseudogenes of the D5 exist. The D2 and D3 receptors vary in certain tissues and species as a result of alternative splicing, and the human D4 receptor gene exhibits extensive polymorphic variation. In the central nervous system, dopamine receptors are widely expressed because they are involved in the control of locomotion, cognition, emotion, and affect as well as neuroendocrine secretion. In the periphery, dopamine receptors are present more prominently in kidney, vasculature, and pituitary, where they affect mainly sodium homeostasis, vascular tone, and hormone secretion. Numerous genetic linkage analysis studies have failed so far to reveal unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders. However, targeted deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions.
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- Authors
- MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1998-01-01
- Volume
- 78
- Issue
- 1
- Pages
- 189-225
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1925492557
- Cited by
- 3,633
- References
- 482
- Citations by year
- 2026: 83 · 2025: 92 · 2024: 122 · 2023: 133 · 2022: 131 · 2021: 130 · 2020: 135 · 2019: 117 · 2018: 110 · 2017: 134 · 2016: 134 · 2015: 157 · 2014: 187 · 2013: 191 · 2012: 189
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine receptors, G protein-coupled receptors, dopamine D1 receptor, dopamine D5 receptor, dopamine D2 receptor, dopamine D3 receptor, dopamine D4 receptor, adenylate cyclase, Gs protein, potassium channels, alternative splicing, genetic polymorphism
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Hypertension, Pituitary Gland, Receptors, Dopamine, Signal Transduction, Animals, Genetically Modified, Mice
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