The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.
Open accessAbstract
The promoters of several eukaryotic genes transcribed by RNA polymerase II contain elements located downstream of the transcriptional start site. To gain insight into how these elements function in the formation of an active transcription complex, we have cloned and sequenced the cDNA that encodes delta, a protein that binds to critical downstream promoter elements in the mouse ribosomal protein rpL30 and rpL32 genes. Our results revealed that the delta protein contains four C-terminal zinc fingers, which are essential for its DNA binding capability and a very unusual N-terminal domain that includes stretches of 11 consecutive negatively charged amino acids and 12 consecutive histidines. The sequence of the delta protein was found to be essentially identical to a concurrently cloned human transcription factor that acts both positively and negatively in the context of immunoglobulin enhancers and a viral promoter. Our structural modeling of this protein indicates properties that could endow it with exquisite functional versatility.
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, A. S., Li, C. H., Zamudio, A. V., Sigova, A. A., Hannett, N. M., Day, D. S., Abraham, B. J., Cohen, M. A., Nabet, B., Buckley, D. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.008 · Cited by 992
Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?
Thomas, M. J., & Seto, E. (1999) · Gene · doi:10.1016/s0378-1119(99)00261-9 · Cited by 465
Regulation of Transcription Factor YY1 by Acetylation and Deacetylation
Yao, Y.-L., Yang, W.-M., & Seto, E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5979-5991.2001 · Cited by 434
Regulation of serum amyloid A protein expression during the acute-phase response
JENSEN, L. E., & WHITEHEAD, A. S. (1998) · Biochemical Journal · doi:10.1042/bj3340489 · Cited by 411
Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation Lethality
Donohoe, M. E., Zhang, X., McGinnis, L., Biggers, J., Li, E., & Shi, Y. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7237 · Cited by 375
Metadata
- Authors
- Hariharan, N., Kelley, D. E., & Perry, R. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-11
- Volume
- 88
- Issue
- 21
- Pages
- 9799-9803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973031832
- Cited by
- 298
- References
- 24
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Hariharan, N., Kelley, D. E., & Perry, R. P. (1991). Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.21.9799
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
