The DOI matches its Crossref record.
Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.
Open accessAbstract
Liver parenchymal cells continuously extract high amounts of bile acids from portal blood plasma. This uptake process is mediated by a Na+/bile acid cotransport system. A cDNA encoding the rat liver bile acid uptake system has been isolated by expression cloning in Xenopus laevis oocytes. The cloned transporter is strictly sodium-dependent and can be inhibited by various non-bile-acid organic compounds. Sequence analysis of the cDNA revealed an open reading frame of 1086 nucleotides coding for a protein of 362 amino acids (calculated molecular mass 39 kDa) with five possible N-linked glycosylation sites and seven putative transmembrane domains. Translation experiments in vitro and in oocytes indicate that the transporter is indeed glycosylated and that its polypeptide backbone has an apparent molecular mass of 33-35 kDa. Northern blot analysis with the cloned probe revealed crossreactivity with mRNA species from rat kidney and intestine as well as from liver tissues of mouse, guinea pig, rabbit, and man.
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Cited by
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Self-citationBile salt transporters: molecular characterization, function, and regulation
Trauner, M., & Boyer, J. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00027.2002 · Cited by 999
Hennemann, G., Docter, R., Friesema, E. C. H., de Jong, M., Krenning, E. P., & Visser, T. J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0435 · Cited by 394
Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216
Thyroid hormone transporters in health and disease
Jansen, J., Friesema, E. C. H., Milici, C., & Visser, T. J. (2005) · Thyroid · doi:10.1089/thy.2005.15.757 · Cited by 181
Boyer, J. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00519.x · Cited by 124
Excretion of biliary compounds during intrauterine life
Macias, R. I., Marin, J. J., & Serrano, M. A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.817 · Cited by 54
Progress in the Molecular Characterization of Hepatobiliary Transporters
Keppler, D. (2017) · Digestive Diseases · doi:10.1159/000450911 · Cited by 33
Metadata
- Authors
- Hagenbuch, B., Stieger, B., Foguet, M., Lübbert, H., & Meier, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-12
- Volume
- 88
- Issue
- 23
- Pages
- 10629-10633
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993689132
- Cited by
- 476
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- green
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