Bile salt transporters: molecular characterization, function, and regulation
Abstract
Molecular medicine has led to rapid advances in the characterization of hepatobiliary transport systems that determine the uptake and excretion of bile salts and other biliary constituents in the liver and extrahepatic tissues. The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1). Other bile salt transporters include the organic anion transporting polypeptides OATPs (SLC21A) and the multidrug resistance-associated proteins 2 and 3 MRP2,3 (ABCC2,3). Bile salt transporters are also present in cholangiocytes, the renal proximal tubule, and the placenta. Expression of these transport proteins is regulated by both transcriptional and posttranscriptional events, with the former involving nuclear hormone receptors where bile salts function as specific ligands. During bile secretory failure (cholestasis), bile salt transport proteins undergo adaptive responses that serve to protect the liver from bile salt retention and which facilitate extrahepatic routes of bile salt excretion. This review is a comprehensive summary of current knowledge of the molecular characterization, function, and regulation of bile salt transporters in normal physiology and in cholestatic liver disease and liver regeneration.
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BA receptors are present in the brain, and BAs can be synthesized locally or actively transported across the BBB by BA transporters from circulation.
“BA receptors are present in the brain, and BAs can either be synthesized locally or actively transported across the BBB by BA transporters from circulation (297, 301, 302).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [301]
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,133 · see citing works
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works
Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714 · see citing works
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S. L., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,347 · see citing works
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274 · see citing works
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085 · see citing works
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940 · see citing works
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819 · see citing works
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687 · see citing works
Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J. R., Kwiterovich, P. O., Shan, B., Barnes, R., & Hobbs, H. H. (2000) · Science · doi:10.1126/science.290.5497.1771 · Cited by 1,645 · see citing works
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636 · see citing works
Nuclear Hormone Receptors and Gene Expression
Aranda, A., & Pascual, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1269 · Cited by 1,562 · see citing works
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512 · see citing works
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487 · see citing works
Smit, J., Schinkel, A. H., Elferink, R. P. J. O., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van ROON, M. A., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90380-9 · Cited by 1,443 · see citing works
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433 · see citing works
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
Staudinger, J. L., Goodwin, B. J., Jones, S. A., Hawkins‐Brown, D., MacKenzie, K. I., Latour, A. M., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,378 · see citing works
Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
Dubyak, G., & El-Moatassim, C. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c577 · Cited by 1,246 · see citing works
Vitamin D Receptor As an Intestinal Bile Acid Sensor
Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science · doi:10.1126/science.1070477 · Cited by 1,176 · see citing works
Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107 · see citing works
Strautnieks, S. S., Bull, L. N., Knisely, A. S., Kocoshis, S. A., Dahl, N., Arnell, H., Sokal, E. M., Dahan, K., Childs, S. J., Ling, V. W. T., et al. (1998) · Nature Genetics · doi:10.1038/3034 · Cited by 995 · see citing works
The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver
Gerloff, T., Stieger, B., Hagenbuch, B., Madon, J., Landmann, L., Roth, J., Hofmann, A. F., & Meier, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.10046 · Cited by 938 · see citing works
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916 · see citing works
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
Synold, T. W., Dussault, I., & FORMAN, B. M. (2001) · Nature Medicine · doi:10.1038/87912 · Cited by 840 · see citing works
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C., Otter, M. Y., Scheffer, G. L., Scheper, R. J., Borst, P., & Elferink, R. P. J. O. (1996) · Science · doi:10.1126/science.271.5252.1126 · Cited by 817 · see citing works
Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D. J., & Suchy, F. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011610200 · Cited by 804 · see citing works
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
Lekstrom-Himes, J., & Xanthopoulos, K. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28545 · Cited by 801 · see citing works
König, J., Nies, A. T., Cui, Y., Leier, I., & KEPPLER, D. O. R. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00169-8 · Cited by 786 · see citing works
Waxman, D. J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1351 · Cited by 754 · see citing works
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
Xie, W., Radominska-p, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., & Evans, R. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051014398 · Cited by 751 · see citing works
A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
Bull, L. N., van Eijk, M. J. T., Pawlikowska, L., DeYoung, J. A., Juijn, J. A., Liao, M., Klomp, L. W. J., Lomri, N., Berger, R., Scharschmidt, B. R., et al. (1998) · Nature Genetics · doi:10.1038/ng0398-219 · Cited by 736 · see citing works
Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis
de Vree, J. M. L., Jacquemin, E., Sturm, E., Cresteil, D., Bosma, P. J., Aten, J., Deleuze, J., Desrochers, M., Burdelski, M. M., Bernard, O., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.282 · Cited by 732 · see citing works
MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS
Mitic, L. L., & Anderson, J. M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.121 · Cited by 721 · see citing works
Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K. E., Meier, P. J., & Hagenbuch, B. (2001) · Gastroenterology · doi:10.1053/gast.2001.21176 · Cited by 718 · see citing works
Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16001 · Cited by 716 · see citing works
Molecular Pathogenesis of Cholestasis
Trauner, M. A., Meier, P. J., & Boyer, J. L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391707 · Cited by 701 · see citing works
Self-citationOverexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
Kozarsky, K., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., & Krieger, M. (1997) · Nature · doi:10.1038/387414a0 · Cited by 697 · see citing works
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
Lee, M., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R. L., SAKUMA, N., Pegoraro, R. J., et al. (2001) · Nature Genetics · doi:10.1038/83799 · Cited by 681 · see citing works
Cui, Y., König, J., Buchholz, U., Spring, H., Leier, I., & KEPPLER, D. O. R. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23190-4 · Cited by 674 · see citing works
Humanized xenobiotic response in mice expressing nuclear receptor SXR
Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander‐Tetri, B. A., Brunt, E. M., Guzelian, P. S., & Evans, R. M. (2000) · Nature · doi:10.1038/35019116 · Cited by 661 · see citing works
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., & Moore, D. D. (2000) · Nature · doi:10.1038/35038112 · Cited by 654 · see citing works
The multidrug resistance protein family
Borst, P., Evers, R., Kool, M., & Wijnholds, J. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00167-4 · Cited by 648 · see citing works
MRP3, an organic anion transporter able to transport anti-cancer drugs
Kool, M., van der Linden, M., de Haas, M., Scheffer, G. L., de Vree, J. M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N. J., Scheper, R. J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6914 · Cited by 645 · see citing works
Büchler, M. W., König, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T., & KEPPLER, D. O. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15091 · Cited by 639 · see citing works
A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)
Hsiang, B. C., Zhu, Y., Wang, Z., Wu, Y., Sasseville, V. G., Yang, W.-P., & Kirchgessner, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37161 · Cited by 638 · see citing works
Tirona, R. G., Leake, B. F., Merino, G., & Kim, R. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103792200 · Cited by 625 · see citing works
König, J., Cui, Y., Nies, A. T., & KEPPLER, D. O. R. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.1.g156 · Cited by 619 · see citing works
Molecular Pathogenesis of Cholestasis
Trauner, M. A., & Jansen, P. L. M. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9034-1 · Cited by 612 · see citing works
Self-citationMutations in ABCC6 cause pseudoxanthoma elasticum
Bergen, A. A. B., Plomp, A. S., Schuurman, E. J. M., Terry, S. F., Breuning, M. H., Dauwerse, H. G., Swart, J., Kool, M., Soest, S. V., Baas, F., et al. (2000) · Nature Genetics · doi:10.1038/76109 · Cited by 590 · see citing works
Meier, P. J., & Stieger, B. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.082201.100300 · Cited by 582 · see citing works
Stieger, B., Fattinger, K. E., Madon, J., Kullak-Ublick, G. A., & Meier, P. J. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70224-1 · Cited by 577 · see citing works
Paulusma, C., Kool, M., Bosma, P., Scheffer, G., Borg, F. T., Scheper, R., Tytgat, G., Borst, P., Baas, F., & Elferink, R. O. O. (1997) · Hepatology · doi:10.1002/hep.510250635 · Cited by 561 · see citing works
Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1
Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17159 · Cited by 543 · see citing works
Expression cloning of a rat liver Na(+)-independent organic anion transporter.
Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A. W., & Meier, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.133 · Cited by 526 · see citing works
Jacquemin, E., Bernard, O., Hadchouel, M., Cresteil, D., de Vree, J. M. L., Paul, M., Elferink, R. P. J. O., Bosma, P. J., Sokal, E. M., Sturm, E., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.23984 · Cited by 522 · see citing works
Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide
König, J., Cui, Y., Nies, A. T., & KEPPLER, D. O. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001448200 · Cited by 520 · see citing works
Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6
Cui, Y., König, J., Leier, I., Buchholz, U., & KEPPLER, D. O. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004968200 · Cited by 510 · see citing works
Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CARPreprint
Xie, W., Barwick, J. L., Simon, C. M., Pierce, A. M., Safe, S. H., Blumberg, B., Guzelian, P. S., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.846800 · Cited by 510 · see citing works
Fattinger, K. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.114667 · Cited by 509 · see citing works
Liver‐enriched transcription factors and hepatocyte differentiation
Cereghini, S. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.2.8641560 · Cited by 505 · see citing works
König, J., Rost, D., Cui, Y., & KEPPLER, D. O. R. (1999) · Hepatology · doi:10.1002/hep.510290404 · Cited by 503 · see citing works
Trauner, M. A., Arrese, M. A., Soroka, C. J., Ananthanarayanan, M., Koeppel, T. A., Schlosser, S., Suchy, F. J., KEPPLER, D. O. R., & Jl, B. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70103-3 · Cited by 500 · see citing works
Self-citationBile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors
Chiang, J. Y. L. (2002) · Endocrine Reviews · doi:10.1210/er.2000-0035 · Cited by 481 · see citing works
Redundant Pathways for Negative Feedback Regulation of Bile Acid Production
Wang, L., Lee, Y., Bundman, D. S., Han, Y., Thevananther, S., Kim, C.-S., Chua, S. S., Wei, P. Y., Heyman, R. A., Karin, M., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00187-9 · Cited by 475 · see citing works
Taniguchi, K., WADA, M., Kohno, K., Nakamura, T., Kawabe, T., Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S.-I., & Kuwano, M. (1996) · PubMed · Cited by 470 · see citing works
Hagenbuch, B., Stieger, B., Foguet, M., Lübbert, H., & Meier, P. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10629 · Cited by 468 · see citing works
Denson, L. A., Sturm, E., Echevarría, W., Zimmerman, T. L., Makishima, M., Mangelsdorf, D. J., & Karpen, S. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.25503 · Cited by 460 · see citing works
Hagenbuch, B., & Meier, P. J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117091 · Cited by 460 · see citing works
Mitic, L. L., Itallie, C. M. V., & Anderson, J. M. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.2.g250 · Cited by 452 · see citing works
Jansen, P. L. M., Strautnieks, S. S., Jacquemin, E., Hadchouel, M., Sokal, E. M., Hooiveld, G. J. E. J., Koning, J. H., de Jager-Krikken, A., Kuipers, F., Stellaard, F., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70287-8 · Cited by 434 · see citing works
Kullak-Ublick, G. A., Hagenbuch, B., Stieger, B., Schteingart, C. D., Hofmann, A. F., Wolkoff, A. W., & Meier, P. J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90588-x · Cited by 429 · see citing works
Shih, D. Q., Bussen, M., Sehayek, E., Ananthanarayanan, M., Shneider, B. L., Suchy, F. J., Shefer, S., Bollileni, J. S., Gonzalez, F. J., Breslow, J. L., et al. (2001) · Nature Genetics · doi:10.1038/86871 · Cited by 422 · see citing works
Gao, B., Hagenbuch, B., Kullak-Ublick, G. A., Benke, D., Aguzzi, A., & Meier, P. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39041-x · Cited by 413 · see citing works
Mechanisms and regulation of bile secretion
Nathanson, M. H., & Boyer, J. L. (1991) · Hepatology · doi:10.1002/hep.1840140324 · Cited by 406 · see citing works
Self-citationKartenbeck, J., Leuschner, U., Mayer, R., & KEPPLER, D. O. R. (1996) · Hepatology · doi:10.1053/jhep.1996.v23.pm0008621134 · Cited by 398 · see citing works
Schuetz, E. G., Strom, S. C., Yasuda, K., Lecureur, V., Assem, M., Brimer, C., Lamba, J. K., Kim, R. B., Ramachandran, V., Komoroski, B. J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106340200 · Cited by 395 · see citing works
Meier, P. J., Sztul, E. S., Reuben, A., & Boyer, J. L. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.3.991 · Cited by 393 · see citing works
Self-citationIsolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
Noé, B., Hagenbuch, B., Stieger, B., & Meier, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10346 · Cited by 392 · see citing works
Ringpfeil, F., Lebwohl, M., Christiano, A. M., & Uitto, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100041297 · Cited by 388 · see citing works
Oelkers, P. M., Kirby, L. C., Heubi, J. E., & Dawson, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119355 · Cited by 379 · see citing works
Bile Acids: The Good, the Bad, and the Ugly
Hofmann, A. F. (1999) · Physiology · doi:10.1152/physiologyonline.1999.14.1.24 · Cited by 376 · see citing works
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy
Jacquemin, E., Cresteil, D., Manouvrier‐Hanu, S., Boute, O., & Hadchouel, M. (1999) · The Lancet · doi:10.1016/s0140-6736(05)77221-4 · Cited by 365 · see citing works
Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors
Sueyoshi, T., & Negishi, M. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.123 · Cited by 362 · see citing works
Vos, T. A., Hooiveld, G. J. E. J., Koning, H., Childs, S. J., Meijer, D. K. F., Moshage, H. J., Jansen, P. L. M., & Müller, M. M. (1998) · Hepatology · doi:10.1002/hep.510280625 · Cited by 362 · see citing works
Kool, M., van der Linden, M., de Haas, M., Baas, F., & Borst, P. (1999) · PubMed · Cited by 361 · see citing works
Meier, P. J., Eckhardt, U., Schroeder, A., Hagenbuch, B., & Stieger, B. (1997) · Hepatology · doi:10.1002/hep.510260641 · Cited by 359 · see citing works
Zollner, G. (2001) · Hepatology · doi:10.1053/jhep.2001.22646 · Cited by 359 · see citing works
Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism
Lu, T. T., Repa, J. J., & Mangelsdorf, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100035200 · Cited by 356 · see citing works
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter.
Wong, M. H., Oelkers, P. M., Craddock, A. L., & Dawson, P. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42263-0 · Cited by 353 · see citing works
Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene
Grober, J., Zaghini, I., Fujii, H., Jones, S. A., Kliewer, S. A., Willson, T. M., Ono, T., & Besnard, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29749 · Cited by 353 · see citing works
Th, M., van Nieuwkerk, C. M., Dingemans, K. P., Smit, J. J., Schinkel, A. H., Notenboom, R. G. E., Weerman, M. A. V. D. B., VERKRUISEN, R. P., Groen, A. K., & Elferink, R. P. J. O. (1994) · PubMed Central · Cited by 352 · see citing works
Hirohashi, T., Suzuki, H. I., & Sugiyama, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15181 · Cited by 351 · see citing works
Kerr, T. A., Saeki, S., Schneider, M., Schaefer, K., Berdy, S., Redder, T., Shan, B., Russell, D. W., & Schwarz, M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00154-5 · Cited by 351 · see citing works
Jansen, P. L. M., Peters, W. H. M., & Lamers, W. H. (1985) · Hepatology · doi:10.1002/hep.1840050408 · Cited by 347 · see citing works
Byrne, J. A., Strautnieks, S. S., Mieli‐Vergani, G., Higgins, C. F., Linton, K. J., & Thompson, R. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.36591 · Cited by 337 · see citing works
ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)
Hirohashi, T., Suzuki, H., Takikawa, H., & Sugiyama, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2905 · Cited by 335 · see citing works
Abe, T., Kakyo, M., Sakagami, H., Tokui, T., Nishio, T., Tanemoto, M., Nomura, H., Hébert, S., Matsuno, S., Kondo, H., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22395 · Cited by 334 · see citing works
Wang, R., Salem, M., Yousef, I. M., Tuchweber, B., Lam, P., Childs, S. J., Helgason, C. D., Ackerley, C. A., Phillips, M. J., & Ling, V. W. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2011 · Cited by 333 · see citing works
Expression of members of the multidrug resistance protein family in human term placenta
St–Pierre, M. V., Serrano, M. A., Macı́as, R. I. R., Dubs, U., Hoechli, M., Lauper, U., Meier, P. J., & Marı́n, J. J. G. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1495 · Cited by 325 · see citing works
Gupta, S., Stravitz, R. T., Dent, P., & Hylemon, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010878200 · Cited by 322 · see citing works
Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Weiglein, A. H., Lammert, F., Marschall, H., Tsybrovskyy, O., Zatloukal, K., Denk, H., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.35948 · Cited by 312 · see citing works
Self-citationKikuchi, S., Hata, M., Fukumoto, K., Yamane, Y., Matsui, T., Tamura, A., Yonemura, S., Yamagishi, H., KEPPLER, D. O. R., Tsukita, S., et al. (2002) · Nature Genetics · doi:10.1038/ng905 · Cited by 308 · see citing works
Craddock, A. L., Love, M. W., Daniel, R. W., Kirby, L. C., Walters, H. C., Wong, M. H., & Dawson, P. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.1.g157 · Cited by 308 · see citing works
Shneider, B. L., Dawson, P. A., Christie, D. M., Hardikar, W., Wong, M. H., & Suchy, F. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117722 · Cited by 307 · see citing works
Lee, Y., Dell, H., Dowhan, D. H., Hadzopoulou‐Cladaras, M., & Moore, D. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.187-195.2000 · Cited by 307 · see citing works
Gao, B., Stieger, B., Noé, B., Fritschy, J., & Meier, P. J. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904701005 · Cited by 304 · see citing works
Molecular aspects of hepatobiliary transport
Müller, M. M., & Jansen, P. L. M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.6.g1285 · Cited by 302 · see citing works
Deleuze, J., Jacquemin, E., Dubuisson, C., et al. (1996) · Hepatology · doi:10.1002/hep.510230435 · Cited by 297 · see citing works
Funk, C., Ponelle, C., Scheuermann, G., & Pantze, M. P. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.627 · Cited by 295 · see citing works
Schaub, T. P., Kartenbeck, J., König, J., Vogel, O., Witzgall, R., Kriz, W., & KEPPLER, D. O. R. (1997) · Journal of the American Society of Nephrology · doi:10.1681/asn.v881213 · Cited by 294 · see citing works
Sequence of mdr3 cDNA encoding a human P-glycoprotein
van der Bliek, A. M., Kooiman, P. M., Schneider, C., et al. (1988) · Gene · doi:10.1016/0378-1119(88)90057-1 · Cited by 293 · see citing works
Suzuki, H. I., & Sugiyama, Y. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00178-0 · Cited by 293 · see citing works
Hepatic Transport of Bile Salts
Kullak-Ublick, G. A., Stieger, B., Hagenbuch, B., & Meier, P. J. (2000) · Seminars in Liver Disease · doi:10.1055/s-2000-9426 · Cited by 292 · see citing works
Up–Regulation of Basolateral Multidrug Resistance Protein 3 (Mrp3) in Cholestatic Rat Liver
Donner, M. G., & KEPPLER, D. O. R. (2001) · Hepatology · doi:10.1053/jhep.2001.26213 · Cited by 291 · see citing works
Plass, J. R. M., Mol, O., Heegsma, J., Geuken, M., Faber, K. N., Jansen, P. L. M., & Müller, M. M. (2002) · Hepatology · doi:10.1053/jhep.2002.31724 · Cited by 291 · see citing works
Soroka, C. J., Lee, J. M., Azzaroli, F., & Boyer, J. L. (2001) · Hepatology · doi:10.1053/jhep.2001.23501 · Cited by 288 · see citing works
Self-citationLi, L., Lee, T. K. M., Meier, P. J., & Ballatori, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16184 · Cited by 277 · see citing works
SECRETION OF ORGANIC ANIONS IN THE FORMATION OF URINE AND BILE
Sperber, I. (1959) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07389-2 · Cited by 271 · see citing works
Byler disease. Fatal familial intrahepatic cholestasis in an Amish kindred.
Clayton, R. J., Iber, F. L., Ruebner, B. H., & McKusick, V. A. (1969) · PubMed · Cited by 268 · see citing works
Clayton, R. J. (1969) · American journal of diseases of children · doi:10.1001/archpedi.1969.02100030114014 · Cited by 267 · see citing works
Tissue Distribution and Induction of Human Multidrug Resistant Protein 3
Scheffer, G. L., Kool, M., de Haas, M., de Vree, J. M. L., Pijnenborg, A. C. L. M., Bosman, D. K., Elferink, R. P. J. O., van der Valk, P., Borst, P., & Scheper, R. J. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780411 · Cited by 266 · see citing works
Trauner, M. A., Arrese, M. A., Lee, H., Boyer, J. L., & Karpen, S. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1680 · Cited by 265 · see citing works
Self-citationFunctional expression of the canalicular bile salt export pump of human liver
Noé, J., Stieger, B., & Meier, P. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.36587 · Cited by 265 · see citing works
Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., & Sugiyama, Y. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13278-6 · Cited by 265 · see citing works
Ji, Y. I., Wang, N., Ramakrishnan, R., Sehayek, E., Huszar, D., Breslow, J. L., & Tall, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33398 · Cited by 263 · see citing works
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Staudinger, J. L., Liu, Y., Madan, A., Habeebu, S. S., & Klaassen, C. D. (2001) · PubMed · Cited by 260 · see citing works
Lazaridis, K. N., Pham, L., Tietz, P. S., Marinelli, R. A., deGroen, P., Levine, S. A., Dawson, P. A., & LaRusso, N. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119816 · Cited by 258 · see citing works
Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Pojer, C., Zenz, R., Lammert, F., Stieger, B., Meier, P. J., Zatloukal, K., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.25542 · Cited by 257 · see citing works
Self-citationWada, M. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.203 · Cited by 256 · see citing works
Gartung, C., Ananthanarayanan, M., Rahman, M. A., Schuele, S., Nundy, S., Soroka, C. J., Stolz, A., Suchy, F. J., & Boyer, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8536857 · Cited by 255 · see citing works
Self-citationCharacterization of inducible nature of MRP3 in rat liver
Ogawa, K., Suzuki, H. I., Hirohashi, T., et al. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.3.g438 · Cited by 254 · see citing works
Paulusma, C. C., van Geer, M. A., Evers, R., Heijn, M., Ottenhoff, R., Borst, P., & Elferink, R. P. J. O. (1999) · Biochemical Journal · doi:10.1042/bj3380393 · Cited by 252 · see citing works
Schaub, T. P., Kartenbeck, J., König, J., Spring, H., Dorsam, J., Staehler, G., Störkel, S., Thon, W., & KEPPLER, D. O. R. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1061159 · Cited by 251 · see citing works
Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
Lee, J. M., Trauner, M. A., Soroka, C. J., et al. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70425-2 · Cited by 250 · see citing works
Self-citationBeuers, U. H., Bilzer, M., CHITTATTU, A., Kullak-Ublick, G. A., KEPPLER, D. O. R., Paumgartner, G., & Dombrowski, F. (2001) · Hepatology · doi:10.1053/jhep.2001.24034 · Cited by 246 · see citing works
Hepatic Secretion of Conjugated Drugs and Endogenous Substances
KEPPLER, D. O. R., & König, J. (2000) · Seminars in Liver Disease · doi:10.1055/s-2000-9391 · Cited by 245 · see citing works
Iliás, A., Urbán, Z., Seidl, T. L., Saux, O. L., Sinkó, E., Boyd, C. D., Sarkadi, B., & Váradi, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110918200 · Cited by 240 · see citing works
Identification of a sister gene to P-glycoprotein.
Childs, S. J., Yeh, R. L., Georges, E., & Ling, V. W. T. (1995) · PubMed · Cited by 237 · see citing works
Transport of amphipathic anions by human multidrug resistance protein 3.
Zeng, H., Liu, G., Rea, P. A., & Kruh, G. D. (2000) · PubMed · Cited by 235 · see citing works
Wong, M. H., Oelkers, P. M., & Dawson, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27228 · Cited by 232 · see citing works
COMPARISON OF RIFAMPICIN WITH PHENOBARBITONE FOR TREATMENT OF PRURITUS IN BILIARY CIRRHOSIS
Bachs, L., Elena, M., Parés, A., Piera, C., & Rodés, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91608-5 · Cited by 231 · see citing works
Kubitz, R., Wettstein, M., Warskulat, U., & Häussinger, D. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70138-1 · Cited by 228 · see citing works
Mayer, R., Kartenbeck, J., Büchler, M. W., Jedlitschky, G., Leier, I., & KEPPLER, D. O. R. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.137 · Cited by 227 · see citing works
Wan, Y. Y., An, D., Cai, Y., Repa, J. J., Chen, T. H.-P., Flores, M., Postic, C., Magnuson, M. A., Chen, J., Chien, K. R., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4436-4444.2000 · Cited by 226 · see citing works
The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver
Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., & Feingold, K. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000953200 · Cited by 223 · see citing works
NF-κB activation in pancreas induces pancreatic and systemic inflammatory response
Chen, X., Ji, B., Han, B., Ernst, S. A., Simeone, D. M., & Logsdon, C. D. (2002) · Gastroenterology · doi:10.1053/gast.2002.31060 · Cited by 222 · see citing works
Oatp2 Mediates Bidirectional Organic Solute Transport: A Role for Intracellular Glutathione
Li, L., Meier, P. J., & Ballatori, N. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.2.335 · Cited by 222 · see citing works
In situ localization of the hepatocytic na+/taurocholate cotransporting polypeptide in rat liver
Stieger, B., Hagenbuch, B., Landmann, L., Höchli, M., Schroeder, A. L., & Meier, P. J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90821-4 · Cited by 218 · see citing works
Transport Function and Hepatocellular Localization of mrp6 in Rat Liver
Madon, J., Hagenbuch, B., Landmann, L., Meier, P. J., & Stieger, B. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.3.634 · Cited by 218 · see citing works
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)1
Kiuchi, Y., Suzuki, H., Hirohashi, T., Tyson, C. A., & Sugiyama, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00899-0 · Cited by 213 · see citing works
Cherrington, N. J., Hartley, D. P., Li, N., Johnson, D. R., & Klaassen, C. D. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.97 · Cited by 212 · see citing works
Tamai, I., Nozawa, T., Koshida, M., Nezu, J., Sai, Y., & Tsuji, A. (2001) · Pharmaceutical Research · doi:10.1023/a:1013077609227 · Cited by 211 · see citing works
Orphan Nuclear Receptors: The Exotics of Xenobiotics
Xie, W., & Evans, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100033200 · Cited by 210 · see citing works
Localization and function of the organic anion–transporting polypeptide Oatp2 in rat liver
Reichel, C., Gao, B., van Montfoort, J. E., Cattori, V., Rahner, C., Hagenbuch, B., Stieger, B., Kamisako, T., & Meier, P. J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70463-4 · Cited by 210 · see citing works
PLASMA MEMBRANES OF THE RAT LIVER
Song, C., Rubin, W., Rifkind, A. B., & Kappas, A. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.41.1.124 · Cited by 209 · see citing works
The state of the STATs: recent developments in the study of signal transduction to the nucleus
Horvath, C. M., & Darnell, J. E., Jr. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80067-1 · Cited by 204 · see citing works
Cui, Y., König, J., & KEPPLER, D. O. R. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.5.934 · Cited by 204 · see citing works
Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system.
Nishida, T., Gatmaitan, Z., Che, M., & Arias, I. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6590 · Cited by 203 · see citing works
Targeted Disruption of the Microsomal Epoxide Hydrolase Gene
Miyata, M., Kudo, G., Lee, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23963 · Cited by 199 · see citing works
Familial intrahepatic cholestasis 1: Studies of localization and function
Ujházy, P., Ortiz, D., Misra, S., Li, S., Moseley, J. B., Jones, H., & Arias, I. M. (2001) · Hepatology · doi:10.1053/jhep.2001.27663 · Cited by 196 · see citing works
Hirohashi, T., Suzuki, H., Chu, X., Tamai, I., Tsuji, A., & Sugiyama, Y. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35286-3 · Cited by 192 · see citing works
New concepts of mechanisms of hepatocyte bile formation.
Boyer, J. L. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.2.303 · Cited by 192 · see citing works
Self-citationYu, J., Lo, J., Huang, L., Zhao, A., Metzger, E., Adams, A., Meinke, P. T., Wright, S. D., & Cui, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200474200 · Cited by 191 · see citing works
Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
Meier, P. J. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.6.g801 · Cited by 191 · see citing works
Denson, L. A., Auld, K. L., Schiek, D. S., McClure, M. H., Mangelsdorf, D. J., & Karpen, S. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8835 · Cited by 187 · see citing works
Transport of Bile Acids in Hepatic and Non-Hepatic Tissues
St–Pierre, M. V., Kullak-Ublick, G. A., Hagenbuch, B., & Meier, P. J. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.10.1673 · Cited by 186 · see citing works
Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
Setchell, K. D. R., Rodrigues, C., Clerici, C., Solinas, A., Morelli, A., Gartung, C., & Boyer, J. L. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70239-7 · Cited by 186 · see citing works
Self-citationDe Vree, J. M. L., Ottenhoff, R., Bosma, P. J., Smith, A. J., Aten, J., & Oude Elferink, R. P. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.20222 · Cited by 186 · see citing works
Alpini, G. D., Glaser, S. S., Ueno, Y., Rodgers, R., Phinizy, J. L., Francis, H., Baiocchi, L., Holcomb, L. A., Caligiuri, A., & LeSage, G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70242-8 · Cited by 185 · see citing works
Expression, transport properties, and chromosomal location of organic anion transporter subtype 3
Walters, H. C., Craddock, A. L., Fusegawa, H., Willingham, M. C., & Dawson, P. A. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.6.g1188 · Cited by 180 · see citing works
Kipp, H., Pichetshote, N., & Arias, I. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007794200 · Cited by 179 · see citing works
Immunologic distribution of an organic anion transport protein in rat liver and kidney
Bergwerk, A. J., Shi, X., Ford, A. C., KANAI, N., Jacquemin, E., Burk, R. D., Bai, S., Novikoff, P. M., Stieger, B., Meier, P. J., et al. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.2.g231 · Cited by 178 · see citing works
Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange
Satlin, L. M., Amin, V., & Wolkoff, A. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26340 · Cited by 177 · see citing works
Müller, M., Ishikawa, T., Berger, U., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55151-6 · Cited by 175 · see citing works
Cattori, V., van Montfoort, J. E., Stieger, B., Landmann, L., Meijer, D. K. F., Winterhalter, K. H., Meier, P. J., & Hagenbuch, B. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100697 · Cited by 175 · see citing works
Alpini, G. D., Glaser, S., Rodgers, R., Phinizy, J. L., Robertson, W., Lasater, J., Caligiuri, A., Tretjak, Z., & LeSage, G. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352879 · Cited by 173 · see citing works
Kullak‐Ublick, G., Glasa, J., Boker, C. A., Oswald, M., Grützner, U., Hagenbuch, B., Stieger, B., Pj, M., Beuers, U. H., Kramer, W., et al. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9322525 · Cited by 173 · see citing works
Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver
Martínez‐Ansó, E., Castillo, J. E. B., Dı́ez, J., Medina, J. F., & Prìeto, J. (1994) · Hepatology · doi:10.1002/hep.1840190613 · Cited by 170 · see citing works
Jung, D., Podvinec, M., Meyer, U., Mangelsdorf, D. J., Fried, M., Meier, P. J., & Kullak-Ublick, G. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.33583 · Cited by 170 · see citing works
Jung, D., Hagenbuch, B., Gresh, L., Pontoglio, M., Meier, P. J., & Kullak-Ublick, G. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103988200 · Cited by 170 · see citing works
Nuclear receptor regulation of hepatic function
Karpen, S. J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00129-0 · Cited by 169 · see citing works
Weisiger, R. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.5.1563 · Cited by 169 · see citing works
Kurz, A. K., Graf, D., Schmitt, M., Dahl, S. V., & Häussinger, D. (2001) · Gastroenterology · doi:10.1053/gast.2001.26262 · Cited by 168 · see citing works
Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia
Hubacek, J. A., Berge, K. E., Cohen, J. C., & Hobbs, H. H. (2001) · Human Mutation · doi:10.1002/humu.1206 · Cited by 166 · see citing works
Rost, D., Mahner, S., Sugiyama, Y., et al. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00318.2001 · Cited by 166 · see citing works
Lee, J., Azzaroli, F., Wang, L., Soroka, C. J., Gigliozzi, A., Setchell, K. D. R., Kramer, W., & Boyer, J. L. (2001) · Gastroenterology · doi:10.1053/gast.2001.29608 · Cited by 166 · see citing works
Self-citationBeuers, U. H., Nathanson, M. H., Isales, C. M., & Boyer, J. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116921 · Cited by 165 · see citing works
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St–Pierre, M. V., Hagenbuch, B., Ugele, B., Meier, P. J., & Stallmach, T. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8431 · Cited by 165 · see citing works
Miyake, J. H., Wang, S.-L., & Davis, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000275200 · Cited by 163 · see citing works
Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters
Simon, F. R., Fortune, J., Iwahashi, M., et al. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.6.g1043 · Cited by 163 · see citing works
Multidrug Resistance and Cancer: The Role of the Human ABC Transporter ABCG2
Ejendal, K. F., & Hrycyna, C. A. (2002) · Current Protein & Peptide Science · doi:10.2174/1389203023380521 · Cited by 161 · see citing works
Kullak-Ublick, G. A., Beuers, U. H., & Paumgartner, G. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80411-0 · Cited by 160 · see citing works
Functional heterogeneity of the intrahepatic biliary epithelium
Kanno, N., LeSage, G., Glaser, S. S., Alvaro, D., & Alpini, G. D. (2000) · Hepatology · doi:10.1002/hep.510310302 · Cited by 158 · see citing works
Regulation of cholangiocyte bicarbonate secretion
Kanno, N., LeSage, G., Glaser, S. S., & Alpini, G. D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g612 · Cited by 158 · see citing works
Bile Salt Sulphates in Cholestasis
Stiehl, A. (1974) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1974.tb00373.x · Cited by 156 · see citing works
Ismair, M. G., Stieger, B., Cattori, V., Hagenbuch, B., Fried, M., Meier, P. J., & Kullak-Ublick, G. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.28704 · Cited by 156 · see citing works
Alpini, G. D., Baiocchi, L., Glaser, S. S., Ueno, Y., Marzioni, M., Francis, H., Phinizy, J. L., Angelico, M., & LeSage, G. (2002) · Hepatology · doi:10.1053/jhep.2002.32712 · Cited by 154 · see citing works
Araya, Z., & Wikvall, K. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00031-1 · Cited by 154 · see citing works
Bile acid profiles in urine of patients with liver diseases
Bremmelgaard, A., & Sjövall, J. (1979) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1979.tb00894.x · Cited by 153 · see citing works
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Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924 · see citing works
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678 · see citing works
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
Targeting bile‐acid signalling for metabolic diseases
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · see citing works
Commensal bacteria at the interface of host metabolism and the immune system
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Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935 · see citing works
Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications
Alrefai, W. A., & Gill, R. K. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9289-1 · Cited by 500 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Wagner, M., Halilbasic, E., Marschall, H., Zollner, G., Fickert, P., Langner, C., Zatloukal, K., Denk, H., & Trauner, M. (2005) · Hepatology · doi:10.1002/hep.20784 · Cited by 355 · see citing works
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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
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Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120019 · Cited by 240 · see citing works
Morgan, R. E., van Staden, C. J., Chen, Y., Kalyanaraman, N., Kalanzi, J., Dunn, R. T., Afshari, C. A., & Hamadeh, H. K. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft176 · Cited by 243 · see citing works
Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216 · see citing works
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Competency of different cell models to predict human hepatotoxic drugs
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Jones, M. L., Tomaro-Duchesneau, C., Martoni, C. J., & Prakash, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.758706 · Cited by 190 · see citing works
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Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
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Zollner, G., & Trauner, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00030.x · Cited by 146 · see citing works
Self-citationScheimann, A. O., Strautnieks, S. S., Knisely, A. S., Byrne, J. A., Thompson, R. J., & Finegold, M. J. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.02.030 · Cited by 138 · see citing works
Sundaram, V., & Björnsson, E. S. (2017) · Hepatology Communications · doi:10.1002/hep4.1088 · Cited by 138 · see citing works
Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134 · see citing works
Bile acids: From digestion to cancers
Baptissart, M., Vega, A., Maqdasy, S., Caira, F., Baron, S., Lobaccaro, J.-M. A., & Volle, D. H. (2013) · Biochimie · doi:10.1016/j.biochi.2012.06.022 · Cited by 97 · see citing works
Pizarro, M., Balasubramaniyan, N., Solís, N., Solar, A., Duarte, I., Miquel, J. F., Suchy, F. J., Trauner, M., Accatino, L., Ananthanarayanan, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037689 · Cited by 87 · see citing works
Self-citationYeh, T.-H., Krauland, L., Singh, V., Zou, B., Devaraj, P., Stolz, D. B., Franks, J., Monga, S. P. S., Sasatomi, E., & Behari, J. (2010) · Hepatology · doi:10.1002/hep.23801 · Cited by 81 · see citing works
Park, Y. J., Qatanani, M., Chua, S. S., LaRey, J. L., Johnson, S. A., Watanabe, M., Moore, D. D., & Lee, Y. K. (2008) · Hepatology · doi:10.1002/hep.22196 · Cited by 68 · see citing works
Geier, A., Dietrich, C. G., Grote, T., Beuers, U., Prüfer, T., Fraunberger, P., Matern, S., Gartung, C., Gerbes, A. L., & Bilzer, M. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.05.031 · Cited by 66 · see citing works
Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00495.x · Cited by 52 · see citing works
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Gupta, K., Ng, I. C., Balachander, G. M., Nguyen, B. P., Tucker-Kellogg, L., Low, B. C., & Yu, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120283 · Cited by 23 · see citing works
- Authors
- Trauner, M., & Boyer, J. L.
- Affiliations
- University of Graz (AT)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2003-04-01
- Volume
- 83
- Issue
- 2
- Pages
- 633-671
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2002121467
- Cited by
- 999
- References
- 416
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 40 · 2023: 23 · 2022: 34 · 2021: 32 · 2020: 39 · 2019: 32 · 2018: 37 · 2017: 51 · 2016: 36 · 2015: 41 · 2014: 52 · 2013: 45 · 2012: 47
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- bile salt transporters, enterohepatic circulation, bile salt export pump, ABCB11, SLC10A2, normal tissue complication probability, SLC10A1, organic anion transporting polypeptides, MRP2, MRP3, cholestasis, nuclear receptors, transcriptional regulation, post-transcriptional regulation, liver regeneration, cholangiocytes, proximal tubule, placenta, bile secretion
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily B, Member 11, Multidrug Resistance-Associated Protein 2, Animals, Bile Acids and Salts, Biological Transport, Cholestasis, Gene Expression Regulation, Humans, Liver Regeneration, ATP-Binding Cassette Transporters
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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