Cited by 999Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismLiver physiology and pathology

Bile salt transporters: molecular characterization, function, and regulation

Trauner, Michael, Boyer, James L.·2003·Physiological Reviews

Abstract

Molecular medicine has led to rapid advances in the characterization of hepatobiliary transport systems that determine the uptake and excretion of bile salts and other biliary constituents in the liver and extrahepatic tissues. The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1). Other bile salt transporters include the organic anion transporting polypeptides OATPs (SLC21A) and the multidrug resistance-associated proteins 2 and 3 MRP2,3 (ABCC2,3). Bile salt transporters are also present in cholangiocytes, the renal proximal tubule, and the placenta. Expression of these transport proteins is regulated by both transcriptional and posttranscriptional events, with the former involving nuclear hormone receptors where bile salts function as specific ligands. During bile secretory failure (cholestasis), bile salt transport proteins undergo adaptive responses that serve to protect the liver from bile salt retention and which facilitate extrahepatic routes of bile salt excretion. This review is a comprehensive summary of current knowledge of the molecular characterization, function, and regulation of bile salt transporters in normal physiology and in cholestatic liver disease and liver regeneration.

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Crossref · 10.1152/physrev.00027.2002

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  • BA receptors are present in the brain, and BAs can be synthesized locally or actively transported across the BBB by BA transporters from circulation.

    “BA receptors are present in the brain, and BAs can either be synthesized locally or actively transported across the BBB by BA transporters from circulation (297, 301, 302).”

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Authors
Trauner, M., & Boyer, J. L.
Affiliations
University of Graz (AT)
Venue
Physiological Reviews
Published
2003-04-01
Volume
83
Issue
2
Pages
633-671
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2002121467
Cited by
999
References
416
Citations by year
2026: 21 · 2025: 34 · 2024: 40 · 2023: 23 · 2022: 34 · 2021: 32 · 2020: 39 · 2019: 32 · 2018: 37 · 2017: 51 · 2016: 36 · 2015: 41 · 2014: 52 · 2013: 45 · 2012: 47
FWCI
6.02
Type
journal article
Language
en
Open access
closed
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
bile salt transporters, enterohepatic circulation, bile salt export pump, ABCB11, SLC10A2, normal tissue complication probability, SLC10A1, organic anion transporting polypeptides, MRP2, MRP3, cholestasis, nuclear receptors, transcriptional regulation, post-transcriptional regulation, liver regeneration, cholangiocytes, proximal tubule, placenta, bile secretion
MeSH terms
ATP Binding Cassette Transporter, Subfamily B, Member 11, Multidrug Resistance-Associated Protein 2, Animals, Bile Acids and Salts, Biological Transport, Cholestasis, Gene Expression Regulation, Humans, Liver Regeneration, ATP-Binding Cassette Transporters

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