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Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.
Open accessAbstract
We previously reported the purification of a complex of two proteins from human chromatin, consisting of a 47-kDa component called RCC1, which is a negative regulator of mitosis, and a 25-kDa protein. Here we show that the 25-kDa protein has a ras-related sequence. It binds guanine nucleotides, and excess Mg2+ and GDP or GTP dissociate the complex. Immunofluorescence studies and biochemical properties indicate that this polypeptide, in contrast to most members of the Ras family, is present in the nucleoplasm as a soluble monomer, in 25-fold excess over the complexed form. We designate this polypeptide Ran, for ras-related nuclear protein.
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Citations
Cited by
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
Moore, M. S., & Blobel, G. (1993) · Nature · doi:10.1038/365661a0 · Cited by 759
Distinct functions for the two importin subunits in nuclear protein import
Görlich, D., Vogel, F., Mills, A. D., Hartmann, E., & Laskey, R. A. (1995) · Nature · doi:10.1038/377246a0 · Cited by 474
Purification of a Ran-interacting protein that is required for protein import into the nucleus.
Moore, M. S., & Blobel, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10212 · Cited by 320
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
Zhang, X., Ems-McClung, S. C., & Walczak, C. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0198 · Cited by 123
Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction
Li, G., D'Souza-Schorey, C., Barbieri, M. A., Cooper, J. A., & Stahl, P. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10337 · Cited by 85
Metadata
- Authors
- Bischoff, F. R., & Ponstingl, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-12
- Volume
- 88
- Issue
- 23
- Pages
- 10830-10834
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2169358645
- Cited by
- 277
- References
- 0
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. https://app.cochat.ai/papers/10.1073/pnas.88.23.10830
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- Bischoff, F. R., & Ponstingl, H. (1991). Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.23.10830
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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