The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.
Open accessAbstract
Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor beta-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL.
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Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Cited by
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Liu, Y., Easton, J., Shao, Y., Maciaszek, J., Wang, Z., Wilkinson, M. R., McCastlain, K., Edmonson, M., Pounds, S. B., Shi, L., et al. (2017) · Nature Genetics · doi:10.1038/ng.3909 · Cited by 918
TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3’ neo-enhancer
Smith, C., Goyal, A., Weichenhan, D., Allemand, E., Mayakonda, A., Toprak, U., Riedel, A., Balducci, E., Manojkumar, M., Pejkovska, A., et al. (2023) · Haematologica · doi:10.3324/haematol.2022.281583 · Cited by 30
Use of inverse PCR to amplify and sequence breakpoints of HPRT deletion and translocation mutations
Williams, M., Rainville, I. R., & Nicklas, J. A. (2002) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10040 · Cited by 15
Metadata
- Authors
- Xia, Y., Brown, L., Yang, C. Y., Tsan, J. T., Siciliano, M. J., Espinosa, R., Le Beau, M. M., & Baer, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-12-15
- Volume
- 88
- Issue
- 24
- Pages
- 11416-11420
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037856863
- Cited by
- 207
- References
- 1
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. https://app.cochat.ai/papers/10.1073/pnas.88.24.11416
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- Xia, Y., Brown, L., Yang, C. Y., Tsan, J. T., Siciliano, M. J., Espinosa, R., Le Beau, M. M., & Baer, R. J. (1991). TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.24.11416
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