The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.
Open accessAbstract
The fibroblast growth factors are a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Fibroblast growth factor receptors (FGFRs) have previously been identified in chicken, mouse, and human and have been shown to contain an extracellular domain with either two or three immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. We have isolated a human cDNA for another tyrosine kinase receptor that is highly homologous to the previously described FGFR. Expression of this receptor cDNA in COS cells directs the expression of a 125-kDa glycoprotein. We demonstrate that this cDNA encodes a biologically active receptor by showing that human acidic and basic fibroblast growth factors activate this receptor as measured by 45Ca2+ efflux assays. These data establish the existence of an additional member of the FGFR family that we have named FGFR-3.
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085
Miki, T., Bottaro, D. P., Fleming, T. P., Smith, C. L., Burgess, W. H., Chan, A. M., & Aaronson, S. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.246 · Cited by 746
Chesi, M., Nardini, E., Brents, L. A., Schröck, E., Ried, T., Kuehl, W. M., & Bergsagel, P. L. (1997) · Nature Genetics · doi:10.1038/ng0797-260 · Cited by 637
A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J., Rutland, P., Reardon, W., Malcolm, S., et al. (1994) · Nature Genetics · doi:10.1038/ng1194-269 · Cited by 614
Metadata
- Authors
- Keegan, K., Johnson, D. E., Williams, L. T., & Hayman, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-02-15
- Volume
- 88
- Issue
- 4
- Pages
- 1095-1099
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2029503020
- Cited by
- 411
- References
- 1
- FWCI
- 20.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Keegan, K., Johnson, D. E., Williams, L. T., & Hayman, M. J. (1991). Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.4.1095
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
