The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.
Open accessAbstract
Expression cDNA cloning and structural analysis of the human keratinocyte growth factor receptor (KGFR) revealed identity with one of the fibroblast growth factor (FGF) receptors encoded by the bek gene (FGFR-2), except for a divergent stretch of 49 amino acids in their extracellular domains. Binding assays demonstrated that the KGFR was a high-affinity receptor for both KGF and acidic FGF, while FGFR-2 showed high affinity for basic and acidic FGF but no detectable binding by KGF. Genomic analysis of the bek gene revealed two alternative exons responsible for the region of divergence between the two receptors. The KGFR transcript was specific to epithelial cells, and it appeared to be differentially regulated with respect to the alternative FGFR-2 transcript. Thus, two growth factor receptors with different ligand-binding specificities and expression patterns are encoded by alternative transcripts of the same gene.
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Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth
Finch, P. W., Rubin, J. S., Miki, T., Ron, D., & Aaronson, S. A. (1989) · Science · doi:10.1126/science.2475908 · Cited by 984
Self-citationPurification and characterization of a newly identified growth factor specific for epithelial cells.
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Self-citationPurification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor
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Self-citationDionne, C. A., Crumley, G., Bellot, F., Kaplow, J. M., Searfoss, G., Ruta, M., Burgess, W. H., Jaye, M., & Schlessinger, J. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07454.x · Cited by 622
Self-citationFGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
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Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop
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Self-citationIsolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.
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Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Function of alternative splicing
Stamm, S., Ben-Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2005) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,377
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
Metadata
- Authors
- Miki, T., Bottaro, D. P., Fleming, T. P., Smith, C. L., Burgess, W. H., Chan, A. M., & Aaronson, S. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-01
- Volume
- 89
- Issue
- 1
- Pages
- 246-250
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088775512
- Cited by
- 746
- References
- 19
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Miki, T., Bottaro, D. P., Fleming, T. P., Smith, C. L., Burgess, W. H., Chan, A. M., & Aaronson, S. A. (1992). Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.1.246
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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