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An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.
Open accessAbstract
An mRNA encoding a helix-loop-helix protein that we have named HLH462 is induced in mouse 3T3 cells as part of the immediate early transcriptional response to growth factors and other signaling agents. The RNA is present in a number of mouse tissues and in the developing mouse fetus. The HLH462 gene has been mapped by interspecific backcross analysis to the distal region of mouse chromosome 4. In its helix-loop-helix region HLH462 is closely related to the Id protein and the Drosophila emc protein. Like Id, HLH462 lacks a basic region required for DNA binding, and it inhibits the DNA-binding activities of other helix-loop-helix proteins. On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development.
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Cites
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
Pelletier, J., & Sonenberg, N. (1985) · Cell · doi:10.1016/0092-8674(85)90200-4 · Cited by 610
Cited by
ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
Norton, J. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3897 · Cited by 665
Id proteins in development, cell cycle and cancer
Ruzinova, M. B., & Benezra, R. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00147-8 · Cited by 570
Jen, Y., Weintraub, H., & Benezra, R. (1992) · Genes & Development · doi:10.1101/gad.6.8.1466 · Cited by 471
Samanta, J., & Kessler, J. A. (2004) · Development · doi:10.1242/dev.01273 · Cited by 361
The Id proteins and angiogenesis
Benezra, R., Rafii, S., & Lyden, D. (2001) · Oncogene · doi:10.1038/sj.onc.1205160 · Cited by 222
Metadata
- Authors
- Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A., & Nathans, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-03
- Volume
- 88
- Issue
- 5
- Pages
- 1815-1819
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026629561
- Cited by
- 338
- References
- 2
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A., & Nathans, D. (1991). An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.5.1815
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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