The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.
Open accessAbstract
We report the cloning and characterization of a cDNA encoding a second human cyclosporin A-binding protein (hCyPB). Homology analyses reveal that hCyPB is a member of the cyclophilin B (CyPB) family, which includes yeast CyPB, Drosophila nina A, and rat cyclophilin-like protein. This family is distinguished from the cyclophilin A (CyPA) family by the presence of endoplasmic reticulum (ER)-directed signal sequences. hCyPB has a hydrophobic leader sequence not found in hCyPA, and its first 25 amino acids are removed upon expression in Escherichia coli. Moreover, we show that hCyPB is a peptidyl-prolyl cis-trans isomerase which can be inhibited by cyclosporin A. These observations suggest that other members of the CyPB family will have similar enzymatic properties. Sequence comparisons of the CyPB proteins show a central, 165-amino acid peptidyl-prolyl isomerase and cyclosporin A-binding domain, flanked by variable N-terminal and C-terminal domains. These two variable regions may impart compartmental specificity and regulation to this family of cyclophilin proteins containing the conserved core domain. Northern blot analyses show that hCyPB mRNA is expressed in the Jurkat T-cell line, consistent with its possible target role in cyclosporin A-mediated immunosuppression.
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Cited by
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ER stress and the unfolded protein response
Schröder, M., & Kaufman, R. J. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.06.056 · Cited by 1,747
Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts
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GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier
Seidner, G., Alvarez, M. G., Yeh, J.-I., O'Driscoll, K. R., Klepper, J., Stump, T. S., Wang, D., Spinner, N. B., Birnbaum, M. J., & De Vivo, D. C. (1998) · Nature Genetics · doi:10.1038/ng0298-188 · Cited by 386
Metadata
- Authors
- Price, E. R., Zydowsky, L. D., Jin, M. J., Baker, C. H., McKeon, F. D., & Walsh, C. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-03
- Volume
- 88
- Issue
- 5
- Pages
- 1903-1907
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024138998
- Cited by
- 314
- References
- 32
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Price, E. R., Zydowsky, L. D., Jin, M. J., Baker, C. H., McKeon, F. D., & Walsh, C. T. (1991). Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.5.1903
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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