The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic organization and diversity of the hepatitis C virus.
Open accessAbstract
The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones. The sequence (9379 nucleotides) has a single large open reading frame that could encode a viral polyprotein precursor of 3011 amino acids. While there as little overall amino acid and nucleotide sequence homology with other viruses, the 5' HCV nucleotide sequence upstream of this large open reading frame has substantial similarity to the 5' termini of pestiviral genomes. The polyprotein also has significant sequence similarity to helicases encoded by animal pestiviruses, plant potyviruses, and human flaviviruses, and it contains sequence motifs widely conserved among viral replicases and trypsin-like proteases. A basic, presumed nucleocapsid domain is located at the N terminus upstream of a region containing numerous potential N-linked glycosylation sites. These HCV domains are located in the same relative position as observed in the pestiviruses and flaviviruses and the hydrophobic profiles of all three viral polyproteins are similar. These combined data indicate that HCV is an unusual virus that is most related to the pestiviruses. Significant genome diversity is apparent within the putative 5' structural gene region of different HCV isolates, suggesting the presence of closely related but distinct viral genotypes.
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Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Cited by
Yoshioka, K., Kakumu, S., Wakita, T., Ishikawa, T., Itoh, Y., Takayanagi, M., Higashi, Y., Shibata, M., & Morishima, T. (1992) · Hepatology · doi:10.1002/hep.1840160203 · Cited by 668
Dusheiko, G., Schmilovitz-Weiss, H., Brown, D., McOmish, F., Yap, P.-L., Sherlock, S., McIntyre, N., & Simmonds, P. (1994) · Hepatology · doi:10.1002/hep.1840190104 · Cited by 561
Wang, C., Sarnow, P., & Siddiqui, A. (1993) · Journal of Virology · doi:10.1128/jvi.67.6.3338-3344.1993 · Cited by 441
Davidson, F., Simmonds, P., Ferguson, J. C., Jarvis, L. M., Dow, B. C., Follett, E. A. C., Seed, C. R. G., Krusius, T., Lin, C., Medgyesi, G. A., et al. (1995) · Journal of General Virology · doi:10.1099/0022-1317-76-5-1197 · Cited by 409
Shih, C. M., Lo, S. J., Miyamura, T., Chen, S. Y., & Lee, Y. H. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.5823-5832.1993 · Cited by 332
Metadata
- Authors
- Choo, Q. L., Richman, K. H., Han, J. H., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, R., & Barr, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-03-15
- Volume
- 88
- Issue
- 6
- Pages
- 2451-2455
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2124528668
- Cited by
- 1,716
- References
- 1
- FWCI
- 84.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Choo, Q. L., Richman, K. H., Han, J. H., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, R., & Barr, P. J. (1991). Genetic organization and diversity of the hepatitis C virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.6.2451
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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