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Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation.
Open accessAbstract
The SNF2, SNF5, and SNF6 genes of Saccharomyces cerevisiae are required for expression of a variety of differently regulated genes. Previous evidence implicated the SNF5 protein in transcriptional activation, and a DNA-bound LexA-SNF5 fusion protein was shown to activate expression of a nearby promoter. Here, we examine the functional relationship of the SNF2, SNF5, and SNF6 proteins. Activation by DNA-bound LexA-SNF5 fusion protein was greatly reduced in snf2 and snf6 mutants, indicating that activation by LexA-SNF5 requires SNF2 and SNF6 function. An spt6 mutation, which suppresses transcriptional defects caused by snf2, restored activation by LexA-SNF5 in a snf2 mutant. The SNF2 gene was sequenced and encodes a 194-kDa protein that is targeted to the nucleus. DNA-bound LexA-SNF2 fusion protein also activated transcription, dependent on SNF5 and SNF6. These findings suggest that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex.
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Citations
Cited by
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Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
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Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729
Transcriptional coactivator complexes.
Näär, A. M., Lemon, B. D., & Tjian, R. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.475 · Cited by 571
Carbon catabolite repression in yeast
GANCEDO, J. M. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16928.x · Cited by 349
Metadata
- Authors
- Laurent, B. C., Treitel, M. A., & Carlson, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-04
- Volume
- 88
- Issue
- 7
- Pages
- 2687-2691
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2062025099
- Cited by
- 240
- References
- 0
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Laurent, B. C., Treitel, M. A., & Carlson, M. (1991). Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.7.2687
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