Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
Open accessAbstract
Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the cell surface. The experiments reported here define an important step in the life cycle of the virus, the release of the budded particle from a tether that binds the assembled particle to the cell surface. Inhibition of the release of the viral capsid proteins by interferon alpha indicates that this step of virus maturation may be sensitive to inhibition by antiviral drugs.
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In HIV-1, the L domains (PTAP and YPXnL) are present in the C-terminally located p6 protein (52 amino acids), deletion of which severely affects virion release, leading to virions bound to the plasma membrane.
“In case of HIV-1, the “L” domains (PTAP and YPXnL) are present in the C-terminally located p6 protein (52 amino acids), deletion of which severely affects virion release, leading to virions bound to the plasma membrane”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Göttlinger et al. 1991
Truncating p2b exerts severe budding defects, similar to those seen in HIV-1 p6 mutants.
“Truncating p2b exerts severe budding defects, similar to those seen in HIV-1 p6 mutants”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Göttlinger et al. 1991
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Göttlinger, H. G., Sodroski, J. G., & Haseltine, W. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5781 · Cited by 841 · see citing works
Self-citationBiochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24
Veronese, F. D., Copeland, T. D., Oroszlan, S., Gallo, R. C., & Sarngadharan, M. G. (1988) · Journal of Virology · doi:10.1128/jvi.62.3.795-801.1988 · Cited by 203 · see citing works
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AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding
Strack, B., Calistri, A., Craig, S., Popova, E., & Göttlinger, H. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00653-6 · Cited by 825 · see citing works
Self-citationHIV-1 Gag proteins: diverse functions in the virus life cycle
Freed, E. O. (1998) · Virology · doi:10.1006/viro.1998.9398 · Cited by 717 · see citing works
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710 · see citing works
VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., & Carter, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131059198 · Cited by 584 · see citing works
Huang, M., Orenstein, J. M., Martin, M. A., & Freed, E. O. (1995) · Journal of Virology · doi:10.1128/jvi.69.11.6810-6818.1995 · Cited by 486 · see citing works
Wiegers, K., Rutter, G., Kottler, H., Tessmer, U., Hohenberg, H., & Kräusslich, H.-G. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2846-2854.1998 · Cited by 336 · see citing works
Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding
Fisher, R. D., Chung, H.-Y., Zhai, Q., Robinson, H., Sundquist, W. I., & Hill, C. P. (2007) · Cell · doi:10.1016/j.cell.2007.01.035 · Cited by 315 · see citing works
Campbell, S., & Rein, A. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2270-2279.1999 · Cited by 293 · see citing works
Ubiquitin is part of the retrovirus budding machinery
Patnaik, A., Chau, V., & Wills, J. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.24.13069 · Cited by 292 · see citing works
Accola, M. A., Strack, B., & Göttlinger, H. G. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5395-5402.2000 · Cited by 288 · see citing works
Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis
Mammano, F., Ohagen, A., Höglund, S., & Göttlinger, H. G. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.4927-4936.1994 · Cited by 254 · see citing works
Self-citationESCRT-III protein requirements for HIV-1 budding
Morita, E., Sandrin, V., McCullough, J., Katsuyama, A., Baci Hamilton, I., & Sundquist, W. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.02.004 · Cited by 242 · see citing works
Role of ESCRT-I in Retroviral Budding
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4794-4804.2003 · Cited by 250 · see citing works
Differential membrane binding of the human immunodeficiency virus type 1 matrix protein
Zhou, W., & Resh, M. D. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8540-8548.1996 · Cited by 226 · see citing works
Puffer, B. A., Parent, L. J., Wills, J. W., & Montelaro, R. C. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6541-6546.1997 · Cited by 217 · see citing works
Demirov, D. G., Orenstein, J. M., & Freed, E. O. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.105-117.2002 · Cited by 201 · see citing works
Accola, M. A., Höglund, S., & Göttlinger, H. G. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2072-2078.1998 · Cited by 196 · see citing works
Park, J., & Morrow, C. D. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.5111-5117.1991 · Cited by 163 · see citing works
Tavassoli, A., Lu, Q., Gam, J., Pan, H., Benkovic, S. J., & Cohen, S. N. (2008) · ACS Chemical Biology · doi:10.1021/cb800193n · Cited by 153 · see citing works
Usami, Y., Popov, S., & Göttlinger, H. G. (2007) · Journal of Virology · doi:10.1128/jvi.00314-07 · Cited by 143 · see citing works
Bukovsky, A., & Göttlinger, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6820-6825.1996 · Cited by 111 · see citing works
Self-citationEbola Virus Matrix Protein VP40 Uses the COPII Transport System for Its Intracellular Transport
Yamayoshi, S., Noda, T., Ebihara, H., Goto, H., Morikawa, Y., Lukashevich, I. S., Neumann, G., Feldmann, H., & Kawaoka, Y. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.001 · Cited by 100 · see citing works
Strack, B., Calistri, A., & Göttlinger, H. G. (2002) · Journal of Virology · doi:10.1128/jvi.76.11.5472-5479.2002 · Cited by 80 · see citing works
Meng, B., Ip, N. C. Y., Prestwood, L. J., Abbink, T. E. M., & Lever, A. M. L. (2015) · Retrovirology · doi:10.1186/s12977-015-0197-x · Cited by 65 · see citing works
Basic Residues in the Nucleocapsid Domain of Gag Are Critical for Late Events of HIV-1 Budding
Dussupt, V., Sette, P., Bello, N. F., Javid, M. P., Nagashima, K., & Bouamr, F. (2011) · Journal of Virology · doi:10.1128/jvi.01562-10 · Cited by 60 · see citing works
Importance of viral late domains in budding and release of enveloped RNA viruses
Welker, L., Paillart, J.-C., & Bernacchi, S. (2021) · Viruses · doi:10.3390/v13081559 · Cited by 36 · see citing works
Wanaguru, M., Barry, D. J., Benton, D. J., O’Reilly, N. J., & Bishop, K. N. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1007117 · Cited by 27 · see citing works
Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication
Jehad, M. A., Ali, L. M., Pillai, V. N., Prabhu, S. G., Mustafa, F., & Rizvi, T. A. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf066 · Cited by 5 · see citing works
“Truncating p2b exerts severe budding defects, similar to those seen in HIV-1 p6 mutants (Göttlinger et al. 1991 , Wills et al. 1994 ).”
- Authors
- Göttlinger, H. G., Dorfman, T., Sodroski, J. G., & Haseltine, W. A.
- Affiliations
- Harvard University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-04-15
- Volume
- 88
- Issue
- 8
- Pages
- 3195-3199
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC51412
- OpenAlex
- W2059841928
- Cited by
- 647
- References
- 2
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 16 · 2013: 21 · 2012: 31
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- amfAR, The Foundation for AIDS Research
- National Institutes of Health (5u01ai024845-09, 5p01gm039599-10)
- National Institute of General Medical Sciences (GM 39599)
- National Institute of Allergy and Infectious Diseases (AI29873, AI24845)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- HIV-1, C-terminal mutations, viral particle release, viral budding, virus maturation, interferon-alpha, antiviral drug sensitivity
- MeSH terms
- Viroporin Proteins, Animals, Base Sequence, Capsid, Cell Membrane, Cells, Cultured, Chlorocebus aethiops, DNA Mutational Analysis, Interferon Type I, Molecular Sequence Data, Oligonucleotides, Protein Precursors, Virus Replication, HIV-1, Gene Products, gag, Human Immunodeficiency Virus Proteins, Viral Regulatory and Accessory Proteins
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