The DOI matches its Crossref record.
Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy.
Open accessAbstract
A method is outlined that completely separates intracellular and extracellular information in NMR spectra of perfused cells. The technique uses diffusion weighting to exploit differences in motional properties between intra- and extracellular constituents. This allows monitoring of intracellular metabolism, and of transport of small drugs and nutrients through the cell membrane, under controlled physiological conditions. As a first example, proton spectra of drug-resistant MCF-7 human breast cancer cells are studied, and uptake of phenylalanine is monitored.
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Citations
Cited by
Niendorf, T., Dijkhuizen, R. M., Norris, D. G., van Lookeren Campagne, M., & Nicolay, K. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360607 · Cited by 570
Theoretical Model for Water Diffusion in Tissues
Szafer, A., Zhong, J., & Gore, J. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330516 · Cited by 521
What can we see with IVIM MRI?
Le Bihan, D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.062 · Cited by 498
Molecular diffusion, tissue microdynamics and microstructure
Bihan, D. L. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080711 · Cited by 497
Cohen, Y., & Assaf, Y. (2002) · NMR in Biomedicine · doi:10.1002/nbm.778 · Cited by 270
Metadata
- Authors
- Van Zijl, P. C., Moonen, C. T., Faustino, P., Pekar, J., Kaplan, O., & Cohen, J. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-04-15
- Volume
- 88
- Issue
- 8
- Pages
- 3228-3232
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025521785
- Cited by
- 220
- References
- 0
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy. https://app.cochat.ai/papers/10.1073/pnas.88.8.3228
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- Van Zijl, P. C., Moonen, C. T., Faustino, P., Pekar, J., Kaplan, O., & Cohen, J. S. (1991). Complete separation of intracellular and extracellular information in NMR spectra of perfused cells by diffusion-weighted spectroscopy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.8.3228
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