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Cited by 570Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

Biexponential diffusion attenuation in various states of brain tissue: Implications for diffusion-weighted imaging

Niendorf, Thoralf, Dijkhuizen, Rick M., Norris, David G., van Lookeren Campagne, Menno, Nicolay, Klaas·1996·Magnetic Resonance in Medicine
DOI 10.1002/mrm.1910360607
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Abstract

Diffusion-weighted single voxel experiments conducted at b-values up to 1 x 10(4) smm-2 yielded biexponential signal attenuation curves for both normal and ischemic brain. The relative fractions of the rapidly and slowly decaying components (f1, f2) are f1 = 0.80 +/- 0.02, f2 = 0.17 +/- 0.02 in healthy adult rat brain and f1 = 0.90 +/- 0.02, f2 = 0.11 +/- 0.01 in normal neonatal rat brain, whereas the corresponding values for the postmortem situation are f1 = 0.69 +/- 0.02, f2 = 0.33 +/- 0.02. It is demonstrated that the changes in f1 and f2 occur simultaneously to those in the extracellular and intracellular space fractions (fex, f(in)) during: (i) cell swelling after total circulatory arrest, and (ii) the recovery from N-methyl-D-aspartate induced excitotoxic brain edema evoked by MK-801, as measured by changes in the electrical impedance. Possible reasons for the discrepancy between the estimated magnitude components and the physiological values are presented and evaluated. Implications of the biexponential signal attenuation curves for diffusion-weighted imaging experiments are discussed.

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  • Early approaches attempted to model curvature in diffusion signal decay arising from co-existence of multiple compartments, sometimes without assigning each component to a specific microstructural entity.

    “Early approaches attempted to model curvature in diffusion signal decay arising from co-existence of multiple compartments (Stanisz et al., 1997), sometimes without assigning each component to a specific microstructural entity (Le Bihan, 1995, 2007; Niendorf et al., 1996).”

    From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Niendorf et al., 1996

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Authors
Niendorf, T., Dijkhuizen, R. M., Norris, D. G., van Lookeren Campagne, M., & Nicolay, K.
Affiliations
  • University of Bremen (DE)
  • University Medical Center Utrecht (NL)
  • Utrecht University (NL)
Corresponding author
Niendorf, Thoralf
ORCID
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1996-12
Volume
36
Issue
6
Pages
847-857
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.1910360607
OpenAlex
W2049685486
Cited by
570
References
0
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 21 · 2019: 14 · 2018: 19 · 2017: 30 · 2016: 27 · 2015: 25 · 2014: 28 · 2013: 30 · 2012: 25
FWCI
7.88
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3298 d)
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
diffusion-weighted imaging, brain tissue, ischemic brain, cell swelling, NMDA receptor, MK-801, electrical impedance, postmortem changes, neonatal brain, circulatory arrest, rat brain
MeSH terms
Age Factors, Animals, Animals, Newborn, Brain Edema, Brain Ischemia, Diffusion, Extracellular Space, Intracellular Fluid, Magnetic Resonance Spectroscopy, Water, N-Methylaspartate, Dizocilpine Maleate, Electric Impedance, Rats, Wistar, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Phantoms, Imaging, Rats

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