The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.
Open accessAbstract
Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development, central hypogonadism in humans could be caused by failure in normal migration of GnRH neurons to the hypothalamus. We report that in transgenic mice expression of the simian virus 40 T antigen, driven by the promoter of human GnRH gene, resulted in central hypogonadism due to an arrest in neuronal migration during development and tumor formation along the migratory pathway. This system appears to be an important animal model of hypogonadotropic hypogonadism in humans. Additionally, olfactory bulb tumors from these animals were dispersed, and a GnRH-secreting neuronal cell line (GN cell line) was established.
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Cites
Origin of luteinizing hormone-releasing hormone neurons
Schwanzel-Fukuda, M., & Pfaff, D. W. (1989) · Nature · doi:10.1038/338161a0 · Cited by 1,116
Wray, S., Nieburgs, A., & Elkabes, S. (1989) · Developmental Brain Research · doi:10.1016/0165-3806(89)90295-2 · Cited by 329
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Cited by
Seminara, S. B., Hayes, F. J., & Crowley, W. F. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.5.0344 · Cited by 414
Errico, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.2.153 · Cited by 342
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 340
Kim, H.-G., Kurth, I., Lan, F., Meliciani, I., Wenzel, W., Eom, S. H., Kang, G. B., Rosenberger, G., Tekin, M., Ozata, M., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.005 · Cited by 338
Suter, K. J. (2000) · Endocrinology · doi:10.1210/en.141.1.412 · Cited by 270
Metadata
- Authors
- Radovick, S., Wray, S., Lee, E., Nicols, D. K., Nakayama, Y., Weintraub, B. D., Westphal, H., Cutler, G. B., & Wondisford, F. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-04-15
- Volume
- 88
- Issue
- 8
- Pages
- 3402-3406
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1997917613
- Cited by
- 209
- References
- 2
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Radovick, S., Wray, S., Lee, E., Nicols, D. K., Nakayama, Y., Weintraub, B. D., Westphal, H., Cutler, G. B., & Wondisford, F. E. (1991). Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.8.3402
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