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The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.
Open accessAbstract
We have previously shown that the human genome includes hundreds of genes coding for putative factors related to the Krüppel zinc-finger protein, which regulates Drosophila segmentation. We report herein that about one-third of these genes code for proteins that share a very conserved region of about 75 amino acids in their N-terminal nonfinger portion. Homologous regions are found in a number of previously described finger proteins, including mouse Zfp-1 and Xenopus Xfin. We named this region the Krüppel-associated box (KRAB). This domain has the potential to form two amphipathic alpha-helices. Southern blot analysis of "zoo" blots suggests that the Krüppel-associated box is highly conserved during evolution. Northern blot analysis shows that these genes are expressed in most adult tissues and are down-regulated during in vitro terminal differentiation of human myeloid cells.
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Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
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DNA Recognition by Cys2His2 Zinc Finger Proteins
Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.183 · Cited by 1,053
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Chong, J. A., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J. J., Zheng, Y., Boutros, M. C., Altshuller, Y. M., Frohman, M. A., Kraner, S. D., & Mandel, G. (1995) · Cell · doi:10.1016/0092-8674(95)90298-8 · Cited by 967
Cancer/testis antigens: an expanding family of targets for cancer immunotherapy
Scanlan., M. J., Gure., A. O., Jungbluth., A. A., Old., L. J., & Chen., Y. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18803.x · Cited by 873
Ecco, G., Imbeault, M., & Trono, D. (2017) · Development · doi:10.1242/dev.132605 · Cited by 389
Huntley, S., Baggott, D. M., Hamilton, A. T., Tran-Gyamfi, M., Yang, S., Kim, J., Gordon, L., Branscomb, E., & Stubbs, L. (2006) · Genome Research · doi:10.1101/gr.4842106 · Cited by 364
Metadata
- Authors
- Bellefroid, E. J., Poncelet, D. A., Lecocq, P. J., Revelant, O., & Martial, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-05
- Volume
- 88
- Issue
- 9
- Pages
- 3608-3612
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974314527
- Cited by
- 375
- References
- 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Bellefroid, E. J., Poncelet, D. A., Lecocq, P. J., Revelant, O., & Martial, J. A. (1991). The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.9.3608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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