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Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.
Open accessAbstract
In an attempt to define the molecular basis of the functional diversity of K+ channels, we have isolated overlapping rat brain cDNAs that encoded a neuronal delayed rectifier K+ channel, K,4, that is structurally related to the Drosophila Shaw protein. Unlike previously characterized mammalian K+ channel genes, which each contain a single protein-coding exon, K,4 arises from alternative exon usage at a locus that also encodes another mammalian Shaw homolog, NGK2. Thus, the enormous diversity of K+ channels in mammals can be generated not just through gene duplication and divergence but also through alternative splicing of RNA.
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Cited by
Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones
Wang, L., Gan, L., Forsythe, I. D., & Kaczmarek, L. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.183bo.x · Cited by 357
Garcia-Calvo, M., Leonard, R. J., Novick, J., Stevens, S. P., Schmalhofer, W., Kaczorowski, G. J., & Garcia, M. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46707-x · Cited by 345
Härtig, W., Derouiche, A., Welt, K., Brauer, K., Grosche, J., Mäder, M., Reichenbach, A., & Brückner, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01784-9 · Cited by 339
Contributions of Kv3 Channels to Neuronal Excitability
RUDY, B., CHOW, A., LAU, D., AMARILLO, Y., OZAITA, A., SAGANICH, M., MORENO, H., NADAL, M. S., HERNANDEZ‐PINEDA, R., HERNANDEZ‐CRUZ, A., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11295.x · Cited by 305
Metadata
- Authors
- Luneau, C. J., Williams, J. B., Marshall, J., Levitan, E. S., Oliva, C., Smith, J. S., Antanavage, J., Folander, K., Stein, R. B., & Swanson, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-05
- Volume
- 88
- Issue
- 9
- Pages
- 3932-3936
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101566513
- Cited by
- 171
- References
- 0
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. https://app.cochat.ai/papers/10.1073/pnas.88.9.3932
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- Luneau, C. J., Williams, J. B., Marshall, J., Levitan, E. S., Oliva, C., Smith, J. S., Antanavage, J., Folander, K., Stein, R. B., & Swanson, R. (1991). Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.9.3932
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