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Cited by 227Multiple Myeloma Research and TreatmentsLymphoma Diagnosis and TreatmentMonoclonal and Polyclonal Antibodies Research

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice

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Suematsu, S, Matsusaka, T, Matsuda, T, Ohno, S, Miyazaki, J, Yamamura, K, Hirano, T, Kishimoto, T·1992·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.89.1.232PMC PMC48210
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Abstract

The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.

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  • IL-6 transgenic mice develop polyclonal plasmacytosis and monoclonal plasmacytoma in C57BL/6 and BALB/c genetic backgrounds, respectively.

    “Accordingly, IL-6 transgenic mice develop polyclonal plasmacytosis and monoclonal plasmacytoma in C57BL/6 and BALB/c genetic backgrounds, respectively (147, 246).”

    From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [246]

    The Abstract reports massive plasmacytosis in C57BL/6-origin IL-6 transgenic mice and monoclonal plasmacytomas after introduction of a BALB/c genetic background. It does not establish that the C57BL/6 plasmacytosis was polyclonal. (LLM, conf=0.82)

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Sorted by citations

Authors
Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T.
Affiliations
  • The University of Osaka (JP)
  • Institute of Resource Development and Analysis, Kumamoto University (JP)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1992-01
Volume
89
Issue
1
Pages
232-235
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.89.1.232
PMC
PMC48210
OpenAlex
W1972932855
Cited by
227
References
0
Citations by year
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FWCI
8.99
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
Keywords
plasmacytoma, interleukin-6, genetic background, BALB/c mice, C57BL/6 mice, pristane, mineral oil, plasmacytosis, multiple myeloma
MeSH terms
Animals, Chromosome Banding, Chromosome Mapping, Mice, Inbred Strains, Mice, Transgenic, Neoplasm Transplantation, Pedigree, Plasmacytoma, Translocation, Genetic, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Interleukin-6, Mice

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