The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin 6: insights to its function in skin by overexpression in transgenic mice.
Open accessAbstract
Interleukin 6 (IL-6) is a cytokine that mediates a wide range of inflammatory and immune responses. Its expression is elevated in inflammatory or immunodeficient diseases, including psoriasis, rheumatoid arthritis, and AIDS. To explore the role of IL-6 in skin, we utilized a human keratin 14 (K14) promoter to express IL-6 in the basal cells of stratified squamous epithelia of transgenic mice. Mice expressing the K14-IL-6 transgene were smaller than normal and exhibited retarded hair growth. Surprisingly, IL-6 expression did not lead to enhanced epidermal proliferation, but it did result in a thicker stratum corneum, with an otherwise seemingly normal program of differentiation. IL-6 expression did not lead to leukocytic infiltration, making it unlikely that it has direct proinflammatory activity in skin. Based on this study, one role of IL-6 relevant to host defense may be to enhance the stratum corneum, thereby providing increased protection from injurious stimuli or infection. If IL-6 plays additional roles in the skin, it is likely to act synergistically with factors that IL-6 alone cannot induce.
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Cites
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
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Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
Watkins, L. R., & Maier, S. F. (2002) · Physiological Reviews · doi:10.1152/physrev.00011.2002 · Cited by 733
De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V, Martini, A., Ciliberto, G., & Fattori, E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119207 · Cited by 529
Huang, X. Z., Wu, J. F., Cass, D., Erle, D. J., Corry, D., Young, S. G., Farese, R. V., & Sheppard, D. (1996) · The Journal of cell biology · doi:10.1083/jcb.133.4.921 · Cited by 316
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
Turksen, K., & Troy, T.-C. (2002) · Development · doi:10.1242/dev.129.7.1775 · Cited by 230
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Metadata
- Authors
- Turksen, K., Kupper, T., Degenstein, L., Williams, I., & Fuchs, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-06
- Volume
- 89
- Issue
- 11
- Pages
- 5068-5072
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166486974
- Cited by
- 225
- References
- 1
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Turksen, K., Kupper, T., Degenstein, L., Williams, I., & Fuchs, E. (1992). Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.11.5068
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