The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
Open accessAbstract
The integrin alpha v beta 6 is only expressed in epithelial cells. In healthy adult epithelia, this receptor is barely detectable, but expression is rapidly induced following epithelial injury. Mice homozygous for a null mutation in the gene encoding the beta 6 subunit had juvenile baldness associated with infiltration of macrophages into the skin, and accumulated activated lymphocytes around conducting airways in the lungs. Beta 6-/- mice also demonstrated airway hyperresponsiveness to acetylcholine, a hallmark feature of asthma. These results suggest that the epithelial integrin alpha v beta 6 participates in the modulation of epithelial inflammation. Genetic or acquired alterations in this integrin could thus contribute to the development of inflammatory diseases of epithelial organs, such as the lungs and skin.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,859
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,865
Integrins: A family of cell surface receptors
HYNES, R. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,249
Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma
Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R., & Kay, A. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260504 · Cited by 2,768
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Mucosal Inflammation in Asthma
Djukanović, R., Roche, W. R., Wilson, J. W., Beasley, C. R. W., Twentyman, O. P., Howarth, P. H., & Holgate, S. T. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.2.434 · Cited by 1,280
The Mechanics of Airway Narrowing in Asthma
James, A. L., Paré, P. D., & Hogg, J. C. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.1.242 · Cited by 789
Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development
Yang, J. T., Rayburn, H., & Hynes, R. O. (1995) · Development · doi:10.1242/dev.121.2.549 · Cited by 787
Corry, D. B., Folkesson, H. G., Warnock, M. L., Erle, D. J., Matthay, M. A., Wiener-Kronish, J. P., & Locksley, R. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.1.109 · Cited by 722
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Metadata
- Authors
- Huang, X. Z., Wu, J. F., Cass, D., Erle, D. J., Corry, D., Young, S. G., Farese, R. V., & Sheppard, D.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-05-15
- Volume
- 133
- Issue
- 4
- Pages
- 921-928
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2133284260
- Cited by
- 316
- References
- 32
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. https://app.cochat.ai/papers/10.1083/jcb.133.4.921
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- Huang, X. Z., Wu, J. F., Cass, D., Erle, D. J., Corry, D., Young, S. G., Farese, R. V., & Sheppard, D. (1996). Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. The Journal of cell biology. https://doi.org/10.1083/jcb.133.4.921
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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