The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Encoded combinatorial chemistry.
Open accessAbstract
The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences. After the chemical entity is bound to a target, the genetic tag can be amplified by replication and utilized for enrichment of the bound molecules by serial hybridization to a subset of the library. The nature of the chemical structure bound to the receptor is decoded by sequencing the nucleotide tag.
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“Originally conceived by Brenner and lerner, Dels are built through iterative chemical synthesis in which each small molecule is covalently linked to a unique DNA tag that enables the parallel screening of millions of pooled compounds (Brenner and lerner 1992).”
From From serendipity to strategy: molecular glue degraders in cancer therapeutics (2025) · cites this paper as Brenner and lerner 1992
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“Conceptualized by Brenner and Lerner, 170 DNA encoded libraries (DELs) are increasingly being adopted in drug discovery.”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [170]
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Cites
Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,421
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,845
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
Fodor, S. P. A., Read, J., Pirrung, M. C., Stryer, L., Lu, A. T., & Solas, D. W. (1991) · Science · doi:10.1126/science.1990438 · Cited by 2,697
Searching for Peptide Ligands with an Epitope Library
Scott, J. K., & Smith, G. P. (1990) · Science · doi:10.1126/science.1696028 · Cited by 2,087
A new type of synthetic peptide library for identifying ligand-binding activity
Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmierski, W. M., & Knapp, R. J. (1991) · Nature · doi:10.1038/354082a0 · Cited by 1,803
Geysen, H. M., Meloen, R. H., & Barteling, S. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.13.3998 · Cited by 1,478
Houghten, R. A., Pinilla, C., Blondelle, S. E., Appel, J. R., Dooley, C. T., & Cuervo, J. H. (1991) · Nature · doi:10.1038/354084a0 · Cited by 1,327
Peptides on phage: a vast library of peptides for identifying ligands.
Cwirla, S. E., Peters, E. A., Barrett, R. W., & Dower, W. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6378 · Cited by 930
Crick, F. H. C., Griffith, J. S., & Orgel, L. E. (1957) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.43.5.416 · Cited by 333
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Research works printed but not linked: 4
- [2]Geysen, H. M., Meloen, R. H. & Barteling, S. J. (1984) Proc. Natl. Acad. Sci. USA 81, 3998–4002.
- [6]Cwirla, S. E., Peters, E. A., Barrett, R. W. & Dower, W. J. (1990) Proc. Natl. Acad. Sci. USA 87, 6378–6382.
- [9]Crick, F. H. C., Griffith, J. S. & Orgel, L. E. (1957) Proc. Natl. Acad. Sci. USA 43, 416–421.
- [10]Merrifield, B. (1984) Les Prix Nobel (Almqvist & Wiksell International, Stockholm), pp. 127–153.
Cited by
Sorted by citations
Ultra-large library docking for discovering new chemotypes
Lyu, J., Wang, S., Balius, T. E., Singh, I., Levit, A., Moroz, Y. S., O’Meara, M. J., Che, T., Algaa, E., Tolmachova, K., et al. (2019) · Nature · doi:10.1038/s41586-019-0917-9 · Cited by 998
PROTACs: past, present and future
Li, K., & Crews, C. M. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00193d · Cited by 869
RNA sequence analysis using covariance models
Eddy, S. R., & Durbin, R. M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.11.2079 · Cited by 791
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Heinis, C., Rutherford, T. J., Freund, S. M. V., & Winter, G. P. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.184 · Cited by 749
“For example, small molecules and a corresponding tag are synthesized in parallel on the same bea”
BackgroundCombinatorial Synthesis of Small Organic Molecules
Balkenhohl, F., Bussche‐Hünnefeld, C. V. D., Lansky, A., & Zechel, C. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199622881 · Cited by 726
Metadata
- Authors
- Brenner, S., & Lerner, R. A.
- Affiliations
- Scripps Research Institute (US)
- ORCID
- Lerner, R A
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1992-06-15
- Volume
- 89
- Issue
- 12
- Pages
- 5381-5383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC49295
- OpenAlex
- W2017423606
- Cited by
- 1,014
- References
- 9
- Citations by year
- 2026: 60 · 2025: 77 · 2024: 71 · 2023: 73 · 2022: 87 · 2021: 72 · 2020: 52 · 2019: 55 · 2018: 30 · 2017: 32 · 2016: 25 · 2015: 24 · 2014: 13 · 2013: 9 · 2012: 8
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
- Keywords
- drug screening, gene tagging, ligand-receptor binding
- MeSH terms
- Amino Acid Sequence, Base Sequence, Molecular Sequence Data, Peptides, Restriction Mapping, Drug Design, Polymerase Chain Reaction, Databases, Factual
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