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A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.
Open accessAbstract
CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD40-Ig, inhibited the induction of B-cell cycle entry, proliferation, and differentiation by activated Th1 and Th2. The ligand for CD40 was identified as a 39-kDa membrane protein that was selectively expressed on activated Th. A monoclonal antibody specific for the 39-kDa protein inhibited CD40-Ig binding and also inhibited the activation of B cells by Th. These data indicate that the 39-kDa membrane protein expressed on activated Th is a binding protein for CD40 and functions to transduce the signal for Th-dependent B-cell activation.
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Citations
Cited by
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
Larsen, C. P., Elwood, E. T., Alexander, D. Z., Ritchie, S. C., Hendrix, R., Tucker-Burden, C., Cho, H. R., Aruffo, A., Hollenbaugh, D., Linsley, P. S., et al. (1996) · Nature · doi:10.1038/381434a0 · Cited by 1,455
Self-citationVinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Mice deficient for the CD40 ligand
Xu, J., Foy, T. M., Laman, J. D., Elliott, E. A., Dunn, J. J., Waldschmidt, T. J., Elsemore, J., Noelle, R. J., & Flavell, R. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90073-6 · Cited by 734
Self-citationA Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T. (1995) · Science · doi:10.1126/science.7618087 · Cited by 538
Metadata
- Authors
- Noelle, R. J., Roy, M., Shepherd, D. M., Stamenkovic, I., Ledbetter, J. A., & Aruffo, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-07-15
- Volume
- 89
- Issue
- 14
- Pages
- 6550-6554
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987968095
- Cited by
- 804
- References
- 0
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. https://app.cochat.ai/papers/10.1073/pnas.89.14.6550
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- Noelle, R. J., Roy, M., Shepherd, D. M., Stamenkovic, I., Ledbetter, J. A., & Aruffo, A. (1992). A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.14.6550
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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