The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
Abstract
CD22 is a membrane immunoglobulin (mIg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mIg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mIg. Ligation of CD22 to prevent its coaggregation with mIg lowers the threshold at which mIg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mIg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mIg signaling to anatomic sites rich in T cells.
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Cites
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Self-citation
Cited by
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 939
Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
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Metadata
- Authors
- Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T.
- Venue
- Science
- Published
- 1995-07-14
- Volume
- 269
- Issue
- 5221
- Pages
- 242-244
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030793757
- Cited by
- 538
- References
- 28
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T. (1995). A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP. Science. https://doi.org/10.1126/science.7618087
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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