The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
Open accessAbstract
The homology between hylobatid chromosomes and other primates has long remained elusive. We used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the chromosomes of primates and establish homologies between the human, great ape (chimpanzee, gorilla, and orangutan), and gibbon karyotypes (Hylobates lar species group, 2n = 44). The hybridization patterns unequivocally demonstrate the high degree of chromosomal homology and synteny of great ape and human chromosomes. Relative to human, no translocations were detected in great apes, except for the well-known fusion-origin of human chromosome 2 and a 5;17 translocation in the gorilla. In contrast, numerous translocations were detected that have led to the massive reorganization of the gibbon karyotype: the 22 autosomal human chromosomes have been divided into 51 elements to compose the 21 gibbon autosomes. Molecular cytogenetics promises to finally allow hylobatids to be integrated into the overall picture of chromosomal evolution in the primates.
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“Hylobatidae (siamang, gibbons, hoolock) are noted for exceptional rates of chromosome re-arrangement [52], [53], 10–20 times faster than in most mammals [54].”
From A molecular phylogeny of living primates (2011) · cites this paper as [53]
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Cites
Pinkel, D., Landegent, J. E., Collins, C. C., Fuscoe, J. C., Segraves, R., Lucas, J. N., & Gray, J. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9138 · Cited by 1,330
Lichter, P., Cremer, T., Borden, J., Manuelidis, L., & Ward, D. C. (1988) · Human Genetics · doi:10.1007/bf01790090 · Cited by 1,160
Self-citationThe Origin of Man: A Chromosomal Pictorial Legacy
Yunis, J. J., & Prakash, O. (1982) · Science · doi:10.1126/science.7063861 · Cited by 672
Cremer, T. J., Lichter, P., Borden, J., Ward, D. C., & Manuelidis, L. (1988) · Human Genetics · doi:10.1007/bf01790091 · Cited by 550
Self-citationDNA hybridization evidence of hominoid phylogeny: Results from an expanded data set
Sibley, C. G., & Ahlquist, J. E. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02111285 · Cited by 300
Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid ProbesPreprint
Pinkel, D., Gray, J. W., Trask, B. J., van den Engh, G., Fuscoe, J. C., & van Dekken, H. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.018 · Cited by 285
Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization
Wienberg, J., Jauch, A. S., Stanyon, R., & Cremer, T. J. (1990) · Genomics · doi:10.1016/0888-7543(90)90292-3 · Cited by 214
Self-citationCollins, C. C., Kuo, W. L., Segraves, R., Fuscoe, J. C., Pinkel, D., & Gray, J. W. (1991) · Genomics · doi:10.1016/0888-7543(91)90025-a · Cited by 207
Wienberg, J., Stanyon, R., Jauch, A. S., & Cremer, T. J. (1992) · Chromosoma · doi:10.1007/bf00346004 · Cited by 177
Self-citationReport of the committee on comparative gene mapping
O'Brien, S. J., Graves, J. A. M., & Renfrey, S. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133025 · Cited by 141
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Poszewiecka, B., Gogolewski, K., Karolak, J. A., Stankiewicz, P., & Gambin, A. (2024) · Figshare · doi:10.6084/m9.figshare.26616739
Poszewiecka, B., Gogolewski, K., Karolak, J. A., Stankiewicz, P., & Gambin, A. (2024) · Figshare · doi:10.6084/m9.figshare.26616742
Generation of Painting Probes from Flow-Sorted and Microdissected Chromosomes
Yang, F., Liehr, T., & Trifonov, V. A. (2026) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-0716-5150-6_7
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Etude des mécanismes évolutifs perturbant l’organisation des gènes dans les génomes de vertébrés
Berthelot, C. (2012) · theses.fr (ABES) · doi:10.70675/69479c04z83b5z4f98zbdefz33141a932dce
Ivanova, S. (2015) · theses.fr (ABES) · doi:10.70675/a8444809z24c5z4458z93eez705549d71c3b
Chromosome painting in plants: history and future perspectives
Jiang, J. (2026) · Chromosome Research · doi:10.1007/s10577-026-09818-1
Metadata
- Authors
- Jauch, A., Wienberg, J., Stanyon, R., Arnold, N., Tofanelli, S., Ishida, T., & Cremer, T.
- Affiliations
- Heidelberg University (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1992-09-15
- Volume
- 89
- Issue
- 18
- Pages
- 8611-8615
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC49970
- OpenAlex
- W1999757424
- Cited by
- 310
- References
- 17
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 9
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- chromosome painting, chromosome homology, synteny, karyotype evolution, translocation, great apes, gibbons, Hylobates, 17 translocation, gorillas, orangutans, chimpanzees, molecular cytogenetics
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Biological Evolution, Hylobates, Karyotyping, Nucleic Acid Hybridization, Species Specificity, Hominidae
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