The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.
Open accessAbstract
Nitric oxide generation in brain cytosolic fractions markedly enhances ADP-ribosylation of a single 37-kDa protein. By utilizing a biotinylated NAD and avidin affinity chromatography, we purified this protein. Partial amino acid sequencing establishes its identity as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This is further confirmed by detection of GAPDH enzymatic activity in the purified 37-kDa protein. GAPDH is ADP-ribosylated in the absence of brain extract. This auto-ADP-ribosylation is enhanced by nitric oxide generation. ADP-ribosylation appears to involve the cysteine where NAD interacts with GAPDH so that ADP-ribosylation likely inhibits enzymatic activity. Such inhibition may play a role in nitric oxide-mediated neurotoxicity.
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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523
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Stanley, W. C., Recchia, F. A., & Lopaschuk, G. D. (2005) · Physiological Reviews · doi:10.1152/physrev.00006.2004 · Cited by 2,048
Housekeeping genes as internal standards: use and limits
Thellin, O., Zorzi, W., Lakaye, B., De Borman, B., Coumans, B., Hennen, G., Grisar, T., Igout, A., & Heinen, E. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00163-7 · Cited by 1,544
Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity
Zhang, J., Dawson, V. L., Dawson, T. M., & Snyder, S. H. (1994) · Science · doi:10.1126/science.8080500 · Cited by 1,118
Self-citationThe diverse functions of GAPDH: Views from different subcellular compartments
Tristan, C., Shahani, N., Sedlak, T. W., & Sawa, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.08.003 · Cited by 663
Metadata
- Authors
- Zhang, J., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-10-15
- Volume
- 89
- Issue
- 20
- Pages
- 9382-9385
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082724267
- Cited by
- 283
- References
- 2
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, J., & Snyder, S. H. (1992). Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.20.9382
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