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A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
Open accessAbstract
Relying on quantitative measurements of Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the endoplasmic reticulum, we construct a simplified kinetic model to describe the properties of this channel. Selecting rate constants to fit key kinetic and equilibrium data, we find that the model reproduces a variety of in vivo and in vitro experiments. In combination with Ca(2+)-ATPase activity for Ca2+ uptake into the endoplasmic reticulum, the model leads to cytoplasmic oscillations in Ca2+ concentration at fixed IP3 concentration and only a single pool of releasable Ca2+, the endoplasmic reticulum. Incorporation of a positive-feedback mechanism of Ca2+ on IP3 production by phospholipase C enriches the properties of the oscillations and leads to oscillations in Ca2+ concentration accompanied by oscillations in IP3 concentration. We discuss the possible significance of these results for the interpretation of experiments.
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Cited by
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Wagner, J., & Keizer, J. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80500-4 · Cited by 477
Self-citationA single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
Atri, A., Amundson, J., Clapham, D., & Sneyd, J. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81191-3 · Cited by 344
Ion channels and signaling in the pituitary gland
Stojilkovic, S. S., Tabak, J., & Bertram, R. (2010) · Endocrine Reviews · doi:10.1210/er.2010-0005 · Cited by 229
Durán-Pastén, M. L., & Fiordelisio, T. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00127 · Cited by 61
Basis for a neuronal version of Grover's quantum algorithm
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Metadata
- Authors
- De Young, G. W., & Keizer, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-10-15
- Volume
- 89
- Issue
- 20
- Pages
- 9895-9899
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2171437709
- Cited by
- 736
- References
- 0
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration. https://app.cochat.ai/papers/10.1073/pnas.89.20.9895
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- De Young, G. W., & Keizer, J. (1992). A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.20.9895
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