The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes.
Open accessAbstract
Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that frequently accompanies this procedure. Recent clinical reports have implied that the use of umbilical cord blood as a source of transplantable stem cells may solve these problems. To date, definitive experiments have not been performed to assess the immunological potential of T cells found in umbilical cord blood, which could mediate graft-versus-host disease. In the present study we have observed that umbilical cord blood contains T lymphocytes that appear to be phenotypically immature. In addition, umbilical cord blood lymphocytes appeared to be functionally immature as shown by minimal responses to stimulation with interleukin 2, phytohemagglutinin, or alloantigens. Thus, umbilical cord blood may be more suitable for allogeneic transplantation than bone marrow in that these cord blood cells may not be as capable of mediating graft-versus-host disease.
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Self-citationThe majority of CD4+8- thymocytes are functionally immature
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Cited by
Rocha, V., Wagner, J. E., Sobocinski, K. A., Klein, J. P., Zhang, M.-J., Horowitz, M. M., & Gluckman, E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422501 · Cited by 868
Development of interleukin-12-producing capacity throughout childhood
Upham, J. W., Lee, P. T., Holt, B. J., Heaton, T., Prescott, S. L., Sharp, M. J., Sly, P. D., & Holt, P. G. (2002) · Infection and Immunity · doi:10.1128/iai.70.12.6583-6588.2002 · Cited by 257
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Yilmaz, A., Cui, H., Caligiuri, M. A., & Yu, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00998-9 · Cited by 171
Metadata
- Authors
- Harris, D. T., Schumacher, M. J., Locascio, J., Besencon, F. J., Olson, G. B., DeLuca, D., Shenker, L., Bard, J., & Boyse, E. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-11
- Volume
- 89
- Issue
- 21
- Pages
- 10006-10010
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070095638
- Cited by
- 342
- References
- 13
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. https://app.cochat.ai/papers/10.1073/pnas.89.21.10006
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- Harris, D. T., Schumacher, M. J., Locascio, J., Besencon, F. J., Olson, G. B., DeLuca, D., Shenker, L., Bard, J., & Boyse, E. A. (1992). Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.21.10006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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