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Cited by 516

The DOI matches its Crossref record.

The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

Open access
Fang, F C, Libby, S J, Buchmeier, N A, Loewen, P C, Switala, J, Harwood, J, Guiney, D G·1992·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.89.24.11978
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Abstract

Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.

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Metadata

Authors
Fang, F. C., Libby, S. J., Buchmeier, N. A., Loewen, P. C., Switala, J., Harwood, J., & Guiney, D. G.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1992-12-15
Volume
89
Issue
24
Pages
11978-11982
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.89.24.11978
OpenAlex
W1989599765
Cited by
516
References
0
FWCI
11.83
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The alternative sigma factor katF (rpoS) regulates Salmonella virulence. https://app.cochat.ai/papers/10.1073/pnas.89.24.11978
The paper
Fang, F. C., Libby, S. J., Buchmeier, N. A., Loewen, P. C., Switala, J., Harwood, J., & Guiney, D. G. (1992). The alternative sigma factor katF (rpoS) regulates Salmonella virulence. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.24.11978

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.