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Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.
Open accessAbstract
A taurine/beta-alanine transporter was cloned from a mouse brain cDNA library by screening with a partial cDNA probe of the glycine transporter at low stringency. The deduced amino acid sequence predicts 590 amino acids with typical characteristics of the sodium-dependent neurotransmitter transporters such as sequence homology and membrane topography. However, the calculated isoelectric point of the taurine/beta-alanine transporter is more acidic (pI = 5.98) than those (pI > 8.0) of other cloned neurotransmitter transporters. Xenopus oocytes injected with cRNA of the cloned transporter expressed uptake activities with Km = 4.5 microM for taurine and Km = 56 microM for beta-alanine. Northern hybridization showed a single transcript of 7.5 kilobases that was highly enriched in kidney and distributed evenly in various parts of the brain. In situ hybridization showed the mRNA of the taurine/beta-alanine transporter to be localized in the corpus callosum, striatum, and anterior commisure. Specific localization of the taurine/beta-alanine transporter in mouse brain suggests a potential function for taurine and beta-alanine as neurotransmitters.
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Cited by
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Metadata
- Authors
- Liu, Q. R., López-Corcuera, B., Nelson, H., Mandiyan, S., & Nelson, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-12-15
- Volume
- 89
- Issue
- 24
- Pages
- 12145-12149
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028386191
- Cited by
- 284
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, Q. R., López-Corcuera, B., Nelson, H., Mandiyan, S., & Nelson, N. (1992). Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.24.12145
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