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Neurotrophin 3 is a mitogen for cultured neural crest cells.
Open accessAbstract
Neurotrophin 3 (NT-3) promotes the survival and induces neurite outgrowth from a subset of neural crest (NC) and placode-derived neurons. We now report that this growth factor regulates the proliferation of cultured NC progenitor cells grown in a serum-free defined medium. In cultures of somites containing NC cells at migratory stages, NT-3 promotes a 2- to 8.4-fold increase in the number of NC cells incorporating [3H]thymidine into nuclei and a 1.8- to 4.8-fold increase in NC cell number compared to controls without added factor. NT-3 also promoted, to a lesser extent, the proliferation of NC cells in homogeneous cultures established from NC clusters. In addition to its effect on NC cells, NT-3 was mitogenic to somite cells in the mixed NC/somite cultures. These data demonstrate that NT-3 can act directly on the NC cells. They also indicate that the response of NC cells to NT-3 may be modulated by the presence of somitic cells. We suggest that NT-3 may be one of the central nervous system-derived factors that mediate NC cell proliferation in vivo.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
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Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
Cattaneo, E., & McKay, R. (1990) · Nature · doi:10.1038/347762a0 · Cited by 717
Cited by
Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
Snider, W. D. (1994) · Cell · doi:10.1016/0092-8674(94)90048-5 · Cited by 1,428
Multiple extracellular signals are required for long-term oligodendrocyte survival
Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
Fariñas, I., Jones, K. R., Backus, C., Wang, X.-Y., & Reichardt, L. F. (1994) · Nature · doi:10.1038/369658a0 · Cited by 638
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Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., & Parada, L. F. (1993) · Development · doi:10.1242/dev.118.2.463 · Cited by 297
Metadata
- Authors
- Kalcheim, C., Carmeli, C., & Rosenthal, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-03
- Volume
- 89
- Issue
- 5
- Pages
- 1661-1665
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1994986028
- Cited by
- 193
- References
- 5
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Kalcheim, C., Carmeli, C., & Rosenthal, A. (1992). Neurotrophin 3 is a mitogen for cultured neural crest cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.5.1661
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
