The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
Open accessAbstract
Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block in T- and B-lymphocyte development. An unusually high incidence of spontaneous thymic lymphoma development was observed after transfer of this mutation from the C.B-17 congenic strain background onto the diabetes-susceptible nonobese diabetic (NOD) background. Thymomagenesis in the NOD-scid/scid mouse was associated with expression of an NOD mouse-unique endogenous ecotropic murine leukemia provirus locus (Emv-30, mapped to proximal region of chromosome 11) not expressed in the standard substrain NOD/Lt thymus. All tumors exhibited insertions of ecotropic proviruses, whereas only a subset also exhibited proviral integrations of mink cell focus-forming retrovirus. Neither class of retrovirus was associated with consistent integration into genes previously associated with activation of oncogenesis. We propose that the unusual features of T-cell ontogeny characteristic of the NOD inbred strain synergize with the scid-imparted block in thymocyte development, leading to activation of the NOD-unique Emv-30 to initiate thymomagenesis.
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Cites
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Cited by
Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,728
Self-citationDevelopment of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice
Ishikawa, F., Yasukawa, M., Lyons, B., Yoshida, S., Miyamoto, T., Yoshimoto, G., Watanabe, T., Akashi, K., Shultz, L. D., & Harada, M. (2005) · Blood · doi:10.1182/blood-2005-02-0516 · Cited by 932
Self-citationOrigin of endothelial progenitors in human postnatal bone marrow
Reyes, M., Dudek, A., Jahagirdar, B., Koodie, L., Marker, P. H., & Verfaillie, C. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214327 · Cited by 887
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Self-citationLeukaemia stem cells and the evolution of cancer-stem-cell research
Huntly, B. J. P., & Gilliland, D. G. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1592 · Cited by 483
Metadata
- Authors
- Prochazka, M., Gaskins, H. R., Shultz, L. D., & Leiter, E. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-04-15
- Volume
- 89
- Issue
- 8
- Pages
- 3290-3294
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965406709
- Cited by
- 279
- References
- 27
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Prochazka, M., Gaskins, H. R., Shultz, L. D., & Leiter, E. H. (1992). The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.8.3290
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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