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Leukaemia stem cells and the evolution of cancer-stem-cell research

Huntly, Brian J. P., Gilliland, D. Gary·2005·Nature Reviews Cancer
DOI 10.1038/nrc1592
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Abstract

Many cancers seem to depend on a small population of 'cancer stem cells' for their continued growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be described. The origins of these cells are controversial, and their biology - like that of their normal-tissue counterpart, the haematopoietic stem cell (HSC) - is still not fully elucidated. However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a thorough understanding of its biology - particularly of how the LSC differs from the HSC - might allow it to be selectively targeted, improving therapeutic outcome.

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Metadata

Authors
Huntly, B. J. P., & Gilliland, D. G.
Venue
Nature Reviews Cancer
Publisher
Springer Science and Business Media LLC
Published
2005-04-01
Volume
5
Issue
4
Pages
311-321
ISSN
  • 1474-175X
  • 1474-1768
DOI
10.1038/nrc1592
Cited by
483
References
8
Language
en
Licence

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