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Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA.
Open accessAbstract
The growth of human hepatoma Hep 3B cells is potently inhibited by TGF-beta 1 (ID50 = 0.2 ng/ml, 8 pM). A mutant cell line was derived that was not inhibited in growth by TGF-beta 1 at 5 ng/ml (200 pM) and that lacked TGF-beta receptor type II (TGF-beta RII) gene. Transfection of the cloned cDNA for human TGF-beta RII to this mutant cell line restored receptor expression as well as the inhibition in growth by TGF-beta 1. In both wild-type and mutant cells stably transfected with TGF-beta RII cDNA, TGF-beta RII coimmunoprecipitated with TGF-beta receptor type I in the presence of ligand. These experiments provide direct evidence for the role of TGF-beta RII in the inhibitory effect of TGF-beta on growth and suggest that TGF-beta RII acts by means of a heteromeric surface complex with TGF-beta receptor type I.
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Cited by
Liu, F., Ventura, F., Doody, J., & Massagué, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3479 · Cited by 593
Activation of Signalling by the Activin Receptor Complex
Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1066 · Cited by 316
Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances
Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06756.x · Cited by 166
Cowin, A. J., Hatzirodos, N., Holding, C. A., Dunaiski, V., Rayner, T. E., Harries, R. H., Fitridge, R., Cooter, R. D., Schultz, G. S., & Belford, D. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01501.x · Cited by 100
Metadata
- Authors
- Inagaki, M., Moustakas, A., Lin, H. Y., Lodish, H. F., & Carr, B. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-06
- Volume
- 90
- Issue
- 11
- Pages
- 5359-5363
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036143395
- Cited by
- 188
- References
- 0
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. https://app.cochat.ai/papers/10.1073/pnas.90.11.5359
- The paper
- Inagaki, M., Moustakas, A., Lin, H. Y., Lodish, H. F., & Carr, B. I. (1993). Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.11.5359
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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