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Expansion of the Hox gene family and the evolution of chordates.
Open accessAbstract
Homeobox genes encode DNA-binding transcription regulators that participate in the formation of embryonic pattern or contribute to cell-type specificity during metazoan development. Homeobox genes that regulate axial patterning and segmental identity (Hox/HOM genes) share a conserved clustered genomic organization. Mammals have four clusters that have likely arisen from the duplication of a single ancestral cluster. The number of Hox-type genes in other deuterostomes was estimated by using a polymerase chain reaction sampling method. Increased Hox gene complements are associated with the appearance of chordate and vertebrate characters. Our data suggest the presence of one Hox cluster in the acorn worm, a hemichordate; two Hox clusters in amphioxus, a cephalochordate; and three in the lamprey, a primitive vertebrate.
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Cites
Neural Crest and the Origin of Vertebrates: A New Head
Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053
Cited by
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Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Polyploid incidence and evolution
Otto, S. P., & Whitton, J. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.401 · Cited by 2,363
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
Lowe, C. J., Wu, M., Salic, A., Evans, L., Lander, E., Stange-Thomann, N., Gruber, C. E., Gerhart, J., & Kirschner, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00469-0 · Cited by 531
Coates, M. I. (1996) · Transactions of the Royal Society of Edinburgh: Earth Sciences · doi:10.1017/s0263593300006787 · Cited by 260
The origin of vertebrate limbs
Coates, M. I. (1994) · Development · doi:10.1242/dev.1994.supplement.169 · Cited by 209
Metadata
- Authors
- Pendleton, J. W., Nagai, B. K., Murtha, M. T., & Ruddle, F. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-07
- Volume
- 90
- Issue
- 13
- Pages
- 6300-6304
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052923559
- Cited by
- 175
- References
- 1
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Pendleton, J. W., Nagai, B. K., Murtha, M. T., & Ruddle, F. H. (1993). Expansion of the Hox gene family and the evolution of chordates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.13.6300
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
