The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Protein oxidative damage is associated with life expectancy of houseflies.
Open accessAbstract
The objective of this study was to test some of the predictions of the oxidative-stress hypothesis of aging, which postulates that aging is causally associated with the molecular damage inflicted by reactive oxygen species. Protein carbonyl content was used as an index of molecular oxidative modifications. The carbonyl content was found to be associated with the physiological age or life expectancy of flies rather than with their chronological age. Exposure of flies to sublethal hyperoxia (100% oxygen) irreversibly enhanced the carbonyl content of the flies and decreased their rate of oxygen consumption. Results of this study indicate that protein carbonyl content may be a biomarker of aging and support the general concept that oxidative stress may be a causal factor in the aging process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Metal-catalyzed oxidation of proteins. Physiological consequences
Stadtman, E. R., & Oliver, C. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52199-2 · Cited by 862
Brash, D. E., Seetharam, S., Kraemer, K. H., Seidman, M. M., & Bredberg, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3782 · Cited by 237
Muriel, W. J., Lamb, J. R., & Lehmann, A. R. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90002-7 · Cited by 21
Cited by
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Protein Oxidation in Aging, Disease, and Oxidative Stress
Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,332
Desiccation tolerance of prokaryotes
Potts, M. (1994) · Microbiological Reviews · doi:10.1128/mr.58.4.755-805.1994 · Cited by 1,382
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Metadata
- Authors
- Sohal, R. S., Agarwal, S., Dubey, A., & Orr, W. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-08
- Volume
- 90
- Issue
- 15
- Pages
- 7255-7259
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088148809
- Cited by
- 354
- References
- 4
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Protein oxidative damage is associated with life expectancy of houseflies. https://app.cochat.ai/papers/10.1073/pnas.90.15.7255
- The paper
- Sohal, R. S., Agarwal, S., Dubey, A., & Orr, W. C. (1993). Protein oxidative damage is associated with life expectancy of houseflies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.15.7255
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
