Heme oxygenase 1 is required for mammalian iron reutilization
Open accessAbstract
The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis. Hmox1-deficient adult mice developed an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iron that contributed to macromolecular oxidative damage, tissue injury, and chronic inflammation. Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.
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Recycling of iron from HB starts with erythrophagocytosis of senescent RBC and involves degradation in the lysosome, separation of heme and globin, and cleavage of heme by HO1 yielding iron, CO and biliverdin.
“The recycling of iron from HB starts with erythrophagocytosis of senescent RBC and involves the degradation of those cells in the lysosome, the separation of heme and globin and the cleavage of heme by HO1 which yields iron, CO and biliverdin (Poss and Tonegawa, 1997).”
From Iron in infection and immunity (2020) · cites this paper as Poss and Tonegawa, 1997
The introduction states that heme oxygenase catabolizes heme to biliverdin, carbon monoxide, and free iron, and the Discussion describes an Hmox1-dependent pathway for iron reutilization (pages not specified in our copy). The paper notes that hemolysis usually occurs in phagocytic cells, but does not describe senescent RBC erythrophagocytosis, lysosomal degradation, or separation of heme from globin as the sequence claimed. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHO-1 deficient mice show enhanced CD4+ T cell activation.
“Accordingly, HO-1 deficient mice show enhanced CD4+ T cell activation (Poss and Tonegawa, 1997).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Poss and Tonegawa, 1997
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- Authors
- Poss, K. D., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-09-30
- Volume
- 94
- Issue
- 20
- Pages
- 10919-10924
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC23531
- OpenAlex
- W2067714284
- Cited by
- 1,016
- References
- 29
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 23 · 2023: 29 · 2022: 28 · 2021: 37 · 2020: 40 · 2019: 31 · 2018: 31 · 2017: 24 · 2016: 23 · 2015: 32 · 2014: 43 · 2013: 32 · 2012: 52
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01-NS32925-03, R01NS032925)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- heme oxygenase-1, iron homeostasis, iron recycling, anemia, serum iron, hepatic iron deposition, oxidative damage, chronic inflammation, erythropoiesis, heme degradation
- MeSH terms
- Anemia, Animals, Female, Heme Oxygenase (Decyclizing), Homeostasis, Iron, Male, Mice, Inbred C57BL, Mutation, Oxidative Stress, Gene Targeting, Mice
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