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Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity.
Open accessAbstract
Immediate-early genes, such as c-fos, are responsive to dopaminergic stimulation in the brain and can have prolonged effects on the transcription of other genes. Thus, they may mediate some of the long-term consequences of altered dopaminergic transmission on striatal neurons, such as the supersensitivity to dopamine and its agonists that occurs in response to dopamine denervation. The two dopamine receptor families, D1 and D2, interact synergistically under normal conditions but independently after treatments that induce pronounced supersensitivity to dopamine agonists. Using immunocytochemical methods in rats treated with directly acting selective dopamine agonists, we have determined that dopamine-mediated expression of Fos and Fos-like antigens in the striatum normally requires concomitant stimulation of D1 and D2 receptors. Separate administration of a high dose of a selective D1 (SKF 38393; 20 mg/kg) or D2 (quinpirole; 3 mg/kg) agonist induced Fos-like immunoreactivity in few neurons, whereas combined administration of the D1 and D2 agonists produced patches of intensely stained immunoreactive nuclei in the caudate-putamen. Repeated administration of reserpine (1 mg/kg per day for 5 days), which causes supersensitivity to dopamine agonists and a breakdown in D1/D2 synergism behaviorally, also causes a change in control of c-fos, such that independent stimulation of D1 receptors by SKF 38393 (20 mg/kg) elicited pronounced Fos-like immunoreactivity in the striatum; combined treatment with SKF 38393 (20 mg/kg) and quinpirole (3 mg/kg) in reserpine-treated rats elicited Fos-like expression in no more neurons than did D1 agonism alone. These data demonstrate that dopamine-mediated Fos expression in the striatum is indicative of the state of D1/D2 synergism and receptor supersensitivity.
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“Under normal conditions, a synergistic balance of D1R- and D2R-like activation exists in striatal regions (Walters et al 1987; LaHoste et al 1993; Gerfen et al 1995; Wise et al 1996; Hu and White 1997).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as LaHoste et al 1993
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Addiction, Dopamine, and the Molecular Mechanisms of Memory
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Metadata
- Authors
- LaHoste, G. J., Yu, J., & Marshall, J. F.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-08-15
- Volume
- 90
- Issue
- 16
- Pages
- 7451-7455
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC47159
- OpenAlex
- W2047619967
- Cited by
- 182
- References
- 35
- Citations by year
- 2023: 2 · 2022: 3 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50mh044188-05, 1r01ns028846-01)
- U.S. Public Health Service
- National Institute of Mental Health (MH44188)
- National Institute of Neurological Disorders and Stroke (NS22698, NS 28846, R01NS022698)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- c-fos, Fos-like immunoreactivity, dopamine D1 receptor, dopamine D2 receptor, receptor supersensitivity, striatum, caudate-putamen, dopamine agonists, reserpine, dopaminergic denervation, immediate early genes, striatal neurons
- MeSH terms
- Animals, Corpus Striatum, Drug Synergism, Ergolines, Immunohistochemistry, Male, Reference Values, Reserpine, Dopamine Agents, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Proto-Oncogene Proteins c-fos, Genes, fos, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Quinpirole, Rats
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