The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.
Open accessAbstract
The endothelins (ETs) form a group of three vasoactive peptides (ET-1, ET-2, and ET-3) for which two types of cellular receptors have been identified, types A and B ET receptors (ETA and ETB receptors, respectively). To address possible targets for ETs within the liver, we isolated the four principal liver cell populations and placed them in short-term primary culture. By ligand-binding assay and mRNA levels, expression of ET receptors was greatest on hepatic lipocytes (Ito cells or fat-storing cells), which are perisinusoidal cells exhibiting features of smooth muscle cells. Moreover, lipocytes expressed both ETA and ETB receptors. The mRNA for ETB receptor, but not for ETA receptor, was detectable in sinusoidal endothelial cells and Kupffer cells; neither mRNA was detectable in hepatocytes. Both ET-1 and ET-3 elicited contraction of activated lipocytes cultured on collagen lattices; the EC50 value for ET-1 was 3 +/- 1 nM and for ET-3 was 17 +/- 12 nM. In cell isolates from injured liver (after administration of carbon tetrachloride), expression of ET receptors was unchanged. However, mRNA for ET-1 was significantly increased in activated lipocytes, suggesting an autocrine loop for the initiation of lipocyte contraction. The findings imply that ET-1 may play a role in regulating sinusoidal perfusion through its effect on lipocytes, particularly in injury states.
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Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Pathogenesis of Liver Fibrosis
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Organogenesis and development of the liver
Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.011 · Cited by 800
Gressner, A. M., & Weiskirchen, R. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00292.x · Cited by 718
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Metadata
- Authors
- Housset, C., Rockey, D. C., & Bissell, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-10-15
- Volume
- 90
- Issue
- 20
- Pages
- 9266-9270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005978449
- Cited by
- 297
- References
- 31
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Housset, C., Rockey, D. C., & Bissell, D. M. (1993). Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.20.9266
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