Organogenesis and development of the liver
Open accessAbstract
Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic functions. Here, we review the basic molecular mechanisms that control the formation of the liver as an organ.
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The temporal emergence of hepatoblasts is in line with previous studies, with specification from the endoderm in early organogenesis (E8.75), migration at E9.5, and the beginnings of hepatoblast function at E10.5.
“The temporal emergence of hepatoblasts is in line with previous studies, with specification from the endoderm in early organogenesis (E8.75), migration at E9.5, and the beginnings of hepatoblast function at E10.5”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Si-Tayeb et al., 2010
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“Though albumin and HNF4A are both very early markers of hepatocyte differentiation (Si-Tayeb et al., 2010), our results indicate that their response to ECM-mediated signaling is differentially regulated.”
- Authors
- Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A.
- Affiliations
- de Duve Institute (BE)
- Medical College of Wisconsin (US)
- Corresponding author
- Duncan, Stephen A.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 18
- Issue
- 2
- Pages
- 175-189
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1985342348
- Cited by
- 800
- References
- 8
- Citations by year
- 2026: 24 · 2025: 41 · 2024: 35 · 2023: 53 · 2022: 70 · 2021: 47 · 2020: 66 · 2019: 50 · 2018: 63 · 2017: 65 · 2016: 53 · 2015: 48 · 2014: 47 · 2013: 54 · 2012: 37
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL094857, R01HL094857)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK66226, R01DK066226, DK 55743, R01DK055743)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- liver development, hepatogenesis, organogenesis, embryonic development, stem cell differentiation, hepatic differentiation
- MeSH terms
- Animals, Biliary Tract, Cell Differentiation, Hematopoiesis, Humans, Kupffer Cells, Liver, Transcription, Genetic, Signal Transduction, Hepatocytes, Endothelial Cells, Mice, Embryonic Stem Cells, Hepatic Stellate Cells
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