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Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery.
Open accessAbstract
Mammalian skin owes its remarkable barrier function to its outermost and dead layer, the stratum corneum. Transdermal transport through this region occurs predominantly through intercellular lipids, organized largely in bilayers. Electroporation is the creation of aqueous pores in lipid bilayers by the application of a short (microseconds to milliseconds) electric pulse. Our measurements suggest that electroporation occurs in the intercellular lipid bilayers of the stratum corneum by a mechanism involving transient structural changes. Flux increases up to 4 orders of magnitude were observed with human skin in vitro for three polar molecules having charges between -1 and -4 and molecular weights up to slightly more than 1000. Similar flux increases were observed in vivo with animal skin. These results may have significance for drug delivery and other medical applications.
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Cited by
Transdermal drug delivery: overcoming the skin’s barrier function
Naik, A., Kalia, Y. N., & Guy, R. H. (2000) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(00)00295-9 · Cited by 720
Electroporation of cells and tissues
Weaver, J. C. (2000) · IEEE Transactions on Plasma Science · doi:10.1109/27.842820 · Cited by 353
Self-citationAdvances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Marjukka Suhonen, T., A. Bouwstra, J., & Urtti, A. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00187-4 · Cited by 310
Multifaceted Design and Emerging Applications of Tissue Adhesives
Ma, Z., Bao, G., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202007663 · Cited by 269
Metadata
- Authors
- Prausnitz, M. R., Bose, V. G., Langer, R., & Weaver, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-11-15
- Volume
- 90
- Issue
- 22
- Pages
- 10504-10508
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2092776514
- Cited by
- 640
- References
- 0
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Prausnitz, M. R., Bose, V. G., Langer, R., & Weaver, J. C. (1993). Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.22.10504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
