The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Advances in transdermal insulin delivery
Open accessAbstract
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Transdermal systems designed to prevent insulin degradation and offer controlled, sustained release of insulin may be desirable for patients and lead to increased adherence and glycemic outcomes. A challenge for transdermal insulin delivery is the inefficient passive insulin absorption through the skin due to the large molecular weight of the protein drug. In this review, we focus on the different transdermal insulin delivery techniques and their respective advantages and limitations, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.
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Cites
The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125
Global estimates of diabetes prevalence for 2013 and projections for 2035
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Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662
Microneedles for drug and vaccine delivery
Kim, Y.-C., Park, J.-H., & Prausnitz, M. R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.04.005 · Cited by 1,760
Williams, A. C., & Barry, B. W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.025 · Cited by 1,746
APPLICATIONS OF ULTRASOUND TO MATERIALS CHEMISTRY
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Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
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Microneedles for transdermal drug delivery
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Cited by
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A. R., Buse, J. B., Langer, R., & Gu, Z. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0508-y · Cited by 604
Self-citationSeyam, S., Nordin, N. A., & Alfatama, M. (2020) · Pharmaceuticals · doi:10.3390/ph13100307 · Cited by 85
Wang, J., Wang, Z., Yu, J., Zhang, Y., Zeng, Y., & Gu, Z. (2019) · Biomaterials Science · doi:10.1039/c9bm01283d · Cited by 21
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Metadata
- Authors
- Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 139
- Pages
- 51-70
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2903909531
- Cited by
- 325
- References
- 183
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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