Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture.
Open accessAbstract
We have developed a quantitative description for calcium permeability of the N-methyl-D-aspartate receptor channel to permit predictions of the reversal potential and calcium influx at different voltages for different extracellular calcium concentrations. Increasing the external calcium concentration markedly shifted the reversal potential to positive values and simultaneously decreased the single-channel conductance at potentials negative to the reversal potential. Very simple quantitative descriptions of calcium permeation and channel block by calcium ions accurately characterize our data and permit the prediction of reversal potentials and magnitudes of calcium influx for a wide range of conditions.
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The driving force for calcium entry is very large for a neuron at rest and the block of NMDARs by Mg2+ is incomplete even at resting potentials, so significant Ca enters the cell in response to synaptic stimulation during low-frequency synaptic stimulation.
“Because the driving force for calcium entry is very large for a neuron at rest and the block of NMDARs by Mg 2þ is incomplete even at resting potentials (Jahr and Stevens 1993), significant Ca enters the cell in response to synaptic stimulation (Sabatini et al. 2002;Bloodgood and Sabatini 2007;Bloodgood et al. 2009) during low-frequency synaptic stimulation.”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Jahr and Stevens 1993
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Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · see citing works
Single cortical neurons as deep artificial neural networks
Beniaguev, D., Segev, I., & London, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.07.002 · Cited by 254 · see citing works
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Self-citation
- Authors
- Jahr, C. E., & Stevens, C. F.
- Affiliations
- Oregon Health & Science University (US)
- ORCID
- Stevens, C F
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-12-15
- Volume
- 90
- Issue
- 24
- Pages
- 11573-11577
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC48026
- OpenAlex
- W1983350404
- Cited by
- 189
- References
- 2
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 7
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- McKnight Endowment Fund for Neuroscience
- McKnight Foundation
- National Institutes of Health (5r01ns012961-22)
- National Institute of Neurological Disorders and Stroke (NS-12961, NS-21419, R01NS021419)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- NMDA receptor, calcium permeability, calcium influx, reversal potential, single-channel conductance, calcium block, hippocampal neurons, quantitative model, voltage dependence
- MeSH terms
- Animals, Animals, Newborn, Calcium, Cell Membrane Permeability, Cells, Cultured, Electric Conductivity, Hippocampus, Kinetics, Mathematics, Membrane Potentials, Models, Neurological, Neurons, Synapses, Thermodynamics, Receptors, N-Methyl-D-Aspartate, Rats
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