Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Abstract
Hippocampal long-term potentiation (LTP) is a remarkably stable facilitation of synaptic responses resulting from very brief trains of high-frequency stimulation. Because of its persistence and modest induction conditions, LTP represents a promising candidate for a substrate of memory. Some progress has been made in localizing the changes responsible for the effect; for example, it has been shown that LTP is not accompanied by changes in the fibre volleys of the test afferents or by generalized alterations of the dendrites of their target cells. However, it is unknown whether the potentiation is due to pre- or postsynaptic changes and there is evidence in favour of each (for example, see refs 5, 6). We now report that intracellular injections of the calcium chelator EGTA block the development of LTP. These results strongly suggest that LTP is caused by a modification of the postsynaptic neurone and that its induction depends on the level of free calcium.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Loading postsynaptic cells with the Ca2+ chelator EGTA blocked LTP, suggesting that Ca2+ is necessary for LTP.
“loading postsynaptic cells with the Ca2+ chelator EGTA blocked LTP (176), suggesting that Ca2+ is necessary for LTP.”
From Synaptic memory and CaMKII (2023) · cites this paper as [176]
Cites
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569 · see citing works
Dunwiddie, T. V., & LYNCH, G. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012239 · Cited by 479 · see citing works
Self-citationAlger, B. E., & Nicoll, R. A. (1980) · Science · doi:10.1126/science.7444438 · Cited by 427 · see citing works
Afterpotential generation in hippocampal pyramidal cells.
Wong, R. K. S., & Prince, D. A. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.45.1.86 · Cited by 397 · see citing works
Long-term potentiation of the perforant path in vivo is associated with increased glutamate release
DOLPHIN, A. C., Errington, M. L., & Bliss, T. V. P. (1982) · Nature · doi:10.1038/297496a0 · Cited by 389 · see citing works
Andersen, P. N., Sundberg, S. H., Sveen, O., Swann, J. W., & Wigström, H. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013256 · Cited by 366 · see citing works
Effects of EGTA on the Calcium-Activated Afterhyperpolarization in Hippocampal CA3 Pyramidal Cells
Schwartzkroin, P. A., & Stafstrom, C. E. (1980) · Science · doi:10.1126/science.6777871 · Cited by 280 · see citing works
Dunwiddie, T. V., & LYNCH, G. S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90377-9 · Cited by 234 · see citing works
Self-citationMicromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes
Baudry, M., Bundman, M. C., Smith, E. K., & LYNCH, G. S. (1981) · Science · doi:10.1126/science.7015504 · Cited by 181 · see citing works
Self-citationRegulation of glutamate receptors by cations
Baudry, M., & LYNCH, G. S. (1979) · Nature · doi:10.1038/282748a0 · Cited by 151 · see citing works
Self-citationBaudry, M., & LYNCH, G. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2298 · Cited by 146 · see citing works
Self-citationSynaptic transmission is required for initiation of long-term potentiation
Dunwiddie, T. V., Madison, D. V., & LYNCH, G. S. (1978) · Brain Research · doi:10.1016/0006-8993(78)90293-7 · Cited by 124 · see citing works
Self-citationLYNCH, G. S., Halpain, S., & Baudry, M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90908-8 · Cited by 119 · see citing works
Self-citationIncrease in glutamate receptors following repetitive electrical stimulation in hippocampal slices
Baudry, M., Oliver, M. E., Creager, R., Wieraszko, A., & LYNCH, G. S. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90200-3 · Cited by 97 · see citing works
Self-citationVargas, F., Greenbaum, L. M., & Costa, E. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90072-6 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489 · see citing works
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835 · see citing works
The physiology of excitatory amino acids in the vertebrate central nervous system
Mayer, M. L., & Westbrook, G. L. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90011-6 · Cited by 1,705 · see citing works
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304 · see citing works
A neuropsychological theory of multiple systems in category learning.
Ashby, F. G., Alfonso-Reese, L. A., Turken, A. U., & Waldron, E. M. (1998) · Psychological Review · doi:10.1037/0033-295x.105.3.442 · Cited by 1,216 · see citing works
Plasticity in the human central nervous system
Cooke, S. F. (2006) · Brain · doi:10.1093/brain/awl082 · Cited by 1,195 · see citing works
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,174 · see citing works
A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation
Schuman, E. M., & Madison, D. V. (1991) · Science · doi:10.1126/science.1720572 · Cited by 1,135 · see citing works
Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
Malinow, R., Schulman, H., & Tsien, R. W. (1989) · Science · doi:10.1126/science.2549638 · Cited by 1,325 · see citing works
The Biochemistry of Memory: A New and Specific Hypothesis
LYNCH, G. S., & Baudry, M. (1984) · Science · doi:10.1126/science.6144182 · Cited by 1,045 · see citing works
Self-citationCalcium regulation of neuronal gene expression
West, A. E., Chen, W. G., Dalva, M., Dolmetsch, R., Kornhauser, J., Shaywitz, A. J., Takasu, M., Tao, X., & Greenberg, M. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191352298 · Cited by 1,115 · see citing works
An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A., & Waxham, M. N. (1989) · Nature · doi:10.1038/340554a0 · Cited by 1,025 · see citing works
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus
Mulkey, R. M., & Malenka, R. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90248-c · Cited by 1,113 · see citing works
NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms
Malenka, R. C., & Nicoll, R. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90197-t · Cited by 904 · see citing works
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T., Garel, S., Charnay, P., Bozon, B., Laroche, S., & Davis, S. (2001) · Nature Neuroscience · doi:10.1038/85138 · Cited by 899 · see citing works
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127 · see citing works
Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037 · see citing works
Self-citationA Brief History of Long-Term Potentiation
Nicoll, R. A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.015 · Cited by 841 · see citing works
Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission
Malenka, R. C., Kauer, J. A., Zucker, R. S., & Nicoll, R. A. (1988) · Science · doi:10.1126/science.2845577 · Cited by 829 · see citing works
Artola, A., & Singer, W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90081-v · Cited by 795 · see citing works
Malinow, R., & Tsien, R. W. (1990) · Nature · doi:10.1038/346177a0 · Cited by 797 · see citing works
Long-term potentiation and functional synapse induction in developing hippocampus
Durand, G. M., Kovalchuk, Y., & Konnerth, A. (1996) · Nature · doi:10.1038/381071a0 · Cited by 789 · see citing works
Nitric Oxide and Synaptic Function
Schuman, E. M., & Madison, D. V. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001101 · Cited by 771 · see citing works
The Life Cycle of Ca2+ Ions in Dendritic Spines
Sabatini, B. L., Oertner, T. G., & Svoboda, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00573-1 · Cited by 745 · see citing works
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
Rosenzweig, E. S., & Barnes, C. A. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00126-0 · Cited by 730 · see citing works
Dendritic Excitability and Synaptic Plasticity
Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 721 · see citing works
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2004) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709 · see citing works
Two components of long-term potentiation induced by different patterns of afferent activation
Grover, L. M., & Teyler, T. J. (1990) · Nature · doi:10.1038/347477a0 · Cited by 708 · see citing works
Deisseroth, K., Bito, H., & Tsien, R. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80026-4 · Cited by 698 · see citing works
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Lee, H.-K., Kameyama, K., Huganir, R. L., & Bear, M. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80632-7 · Cited by 668 · see citing works
Gally, J. A., Montague, P. R., Reeke, G. N., & Edelman, G. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3547 · Cited by 644 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
Potentiation of synaptic transmission in the hippocampus by phorbol esters
Malenka, R. C., Madison, D. V., & Nicoll, R. A. (1986) · Nature · doi:10.1038/321175a0 · Cited by 633 · see citing works
Yuste, R., & Katz, L. C. (1991) · Neuron · doi:10.1016/0896-6273(91)90243-s · Cited by 591 · see citing works
Hebbian synapses in hippocampus.
Kelso, S. R., Ganong, A. H., & Brown, T. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5326 · Cited by 555 · see citing works
Self-citationThe current excitement in long term potentiation
Nicoll, R. A., Kauer, J. A., & Malenka, R. C. (1988) · Neuron · doi:10.1016/0896-6273(88)90193-6 · Cited by 535 · see citing works
The Role of NMDA Receptors in Alzheimer’s Disease
Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535 · see citing works
A Physiological Basis for a Theory of Synapse Modification
Bear, M. F., Cooper, L. N., & Ebner, F. F. (1987) · Science · doi:10.1126/science.3037696 · Cited by 528 · see citing works
Mayford, M. R., Wang, J., Kandel, E. R., & O’Dell, T. J. (1995) · Cell · doi:10.1016/0092-8674(95)90009-8 · Cited by 525 · see citing works
The CaM kinase II hypothesis for the storage of synaptic memory.
Lisman, J. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90014-0 · Cited by 526 · see citing works
Mayford, M., Siegelbaum, S. A., & Kandel, E. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005751 · Cited by 500 · see citing works
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
Kauer, J. A., Malenka, R. C., & Nicoll, R. A. (1988) · Neuron · doi:10.1016/0896-6273(88)90148-1 · Cited by 497 · see citing works
Bear, M., Kleinschmidt, A., Gu, Q., & Singer, W. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-03-00909.1990 · Cited by 488 · see citing works
Activity-Dependent Changes in the Intrinsic Properties of Cultured Neurons
Turrigiano, G. G., Abbott, L. F., & Marder, E. E. (1994) · Science · doi:10.1126/science.8178157 · Cited by 484 · see citing works
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481 · see citing works
Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses
Müller, W. S., & Connor, J. A. (1991) · Nature · doi:10.1038/354073a0 · Cited by 479 · see citing works
Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events
Larson, J., & Lynch, G. (1986) · Science · doi:10.1126/science.3704635 · Cited by 597 · see citing works
Self-citationMyosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity
Wang, Z., Edwards, J. G., Riley, N., Provance, D. W., Karcher, R., Li, X.-D., Davison, I. G., Ikebe, M., Mercer, J. A., Kauer, J. A., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.057 · Cited by 470 · see citing works
Cheng, B., & Mattson, M. P. (1991) · Neuron · doi:10.1016/0896-6273(91)90347-3 · Cited by 460 · see citing works
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989) · Science · doi:10.1126/science.2704997 · Cited by 458 · see citing works
Spine Ca<sup>2+</sup>Signaling in Spike-Timing-Dependent Plasticity
Nevian, T., & Sakmann, B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1749-06.2006 · Cited by 458 · see citing works
Sacktor, T. C., Osten, P., Valsamis, H. A., Jiang, X., Naik, M. U., & Sublette, M. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8342 · Cited by 450 · see citing works
Ca2+ signaling requirements for long-term depression in the hippocampus.
Cummings, J. A., Mulkey, R., Nicoll, R., & Malenka, R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80102-6 · Cited by 471 · see citing works
Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons
Sah, P., Hestrin, S., & Nicoll, R. A. (1989) · Science · doi:10.1126/science.2573153 · Cited by 443 · see citing works
Malgaroli, A., & Tsien, R. (1992) · Nature · doi:10.1038/357134a0 · Cited by 384 · see citing works
Long-Term Synaptic Potentiation
Brown, T. H., Chapman, P. F., Kairiss, E. W., & Keenan, C. L. (1988) · Science · doi:10.1126/science.2903551 · Cited by 415 · see citing works
Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490 · see citing works
Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism
Herron, C. E., Lester, R. A. J., Coan, E. J., & Collingridge, G. L. (1986) · Nature · doi:10.1038/322265a0 · Cited by 412 · see citing works
Egger, V., Feldmeyer, D., & Sakmann, B. J. (1999) · Nature Neuroscience · doi:10.1038/16026 · Cited by 405 · see citing works
Colbran, R. J., Schworer, C. M., Hashimoto, Y., Fong, Y. L., Rich, D. P., Smith, M. K., & Soderling, T. R. (1989) · Biochemical Journal · doi:10.1042/bj2580313 · Cited by 406 · see citing works
Glutamate: its role in learning, memory, and the aging brain
McEntee, W. J., & Crook, T. H. (1993) · Psychopharmacology · doi:10.1007/bf02253527 · Cited by 404 · see citing works
Physiological mechanisms underlying long-term potentiation
Gustafsson, B., & Wigström, H. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90142-7 · Cited by 398 · see citing works
The BCM theory of synapse modification at 30: interaction of theory with experiment
Cooper, L. N., & Bear, M. F. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3353 · Cited by 395 · see citing works
The spread of Na+ spikes determines the pattern of dendritic Ca2+ entry into hippocampal neurons
Jaffe, D. B., Johnston, D., Lasser‐Ross, N., Lisman, J. E., Miyakawa, H., & Ross, W. N. (1992) · Nature · doi:10.1038/357244a0 · Cited by 396 · see citing works
Calcium-Mediated Reduction of Ionic Currents: A Biophysical Memory Trace
Alkon, D. L. (1984) · Science · doi:10.1126/science.6093258 · Cited by 393 · see citing works
Calcium and the aging nervous system
Gibson, G. E., & Peterson, C. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90072-8 · Cited by 386 · see citing works
Learning to modulate transmitter release: themes and variations in synaptic plasticity.
Hawkins, R. D., Kandel, E., & Siegelbaum, S. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.003205 · Cited by 404 · see citing works
From form to function: calcium compartmentalization in dendritic spines
Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works
The comparative psychology of intelligence
Macphail, E. M. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00054984 · Cited by 371 · see citing works
Glioma synapses recruit mechanisms of adaptive plasticity
Taylor, K. R., Barron, T., Hui, A., Spitzer, A., Yalçın, B., Ivec, A. E., Geraghty, A. C., Hartmann, G. G., Arzt, M., Gillespie, S. M., et al. (2023) · Nature · doi:10.1038/s41586-023-06678-1 · Cited by 355 · see citing works
Calcium signaling in neurodegeneration
Marambaud, P., Dreses‐Werringloer, U., & Vingtdeux, V. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-20 · Cited by 352 · see citing works
Siman, R. G., Noszek, J. C., & Kegerise, C. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01579.1989 · Cited by 352 · see citing works
Ca(2+) signaling in dendritic spines.
Sabatini, B., Maravall, M., & Svoboda, K. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00218-x · Cited by 340 · see citing works
Locally Distributed Synaptic Potentiation in the Hippocampus
Schuman, E. M., & Madison, D. V. (1994) · Science · doi:10.1126/science.8290963 · Cited by 352 · see citing works
Protein kinase C modulation of NMDA currents: an important link for LTP induction
Ben‐Ari, Y., Aniksztejn, L., & Bregestovski, P. D. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90049-e · Cited by 343 · see citing works
A Spatial-Temporal Model of Cell Activation
Alkon, D. L., & Rasmussen, H. (1988) · Science · doi:10.1126/science.2830669 · Cited by 342 · see citing works
NMDA application potentiates synaptic transmission in the hippocampus
Kauer, J. A., Malenka, R. C., & Nicoll, R. A. (1988) · Nature · doi:10.1038/334250a0 · Cited by 423 · see citing works
Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.
Böhme, G. A., Bon, C. L. M., Lemaire, M., Reibaud, M., Piot, O., Stutzmann, J. M., Doble, A., & Blanchard, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9191 · Cited by 337 · see citing works
NEURAL MECHANISMS OF MAMMALIAN OLFACTORY LEARNING
Brennan, P., & Keverne, E. B. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00069-x · Cited by 334 · see citing works
Long-term potentiation and long-term depression: a clinical perspective
Bliss, T. V. P., & Cooke, S. F. (2011) · Clinics · doi:10.1590/s1807-59322011001300002 · Cited by 333 · see citing works
Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases
Nguyen, P., & Woo, N. H. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.12.003 · Cited by 324 · see citing works
Long-term potentiation and long-term depression in the neocortex
Tsumoto, T. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90011-3 · Cited by 327 · see citing works
Calcium regulation of gene expression in neuronal cells
Ghosh, A., Ginty, D. D., Bading, H., & Greenberg, M. E. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250309 · Cited by 326 · see citing works
Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region
Blitzer, R. D., Wong, T., Nouranifar, R., Iyengar, R., & Landau, E. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90018-7 · Cited by 325 · see citing works
Malinow, R., & Miller, J. P. (1986) · Nature · doi:10.1038/320529a0 · Cited by 323 · see citing works
Long-term potentiation: What's learning got to do with it?
Shors, T. J., & Matzel, L. D. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97001593 · Cited by 314 · see citing works
Molecular machines integrate coincident synaptic signals
Bourne, H. R., & Nicoll, R. A. (1993) · Cell · doi:10.1016/s0092-8674(05)80029-7 · Cited by 311 · see citing works
Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39887 · Cited by 301 · see citing works
Arancio, O., Kandel, E. R., & Hawkins, R. D. (1995) · Nature · doi:10.1038/376074a0 · Cited by 301 · see citing works
Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation
Staubli, U. V., & LYNCH, G. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)91096-y · Cited by 301 · see citing works
Self-citationSignaling from cAMP/PKA to MAPK and Synaptic Plasticity
Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 300 · see citing works
Sustained Dendritic Gradients of Ca 2+ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons
Connor, J. A., Wadman, W. J., Hockberger, P. E., & Wong, R. K. S. (1988) · Science · doi:10.1126/science.2452481 · Cited by 299 · see citing works
- Authors
- Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Lynch, Gary
- Venue
- Nature
- Published
- 1983-10
- Volume
- 305
- Issue
- 5936
- Pages
- 719-721
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2031739172
- Cited by
- 1,116
- References
- 16
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 25 · 2018: 18 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 17 · 2013: 19 · 2012: 28
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, hippocampus, EGTA, calcium chelation, intracellular injection, free calcium, synaptic plasticity, memory substrate, high-frequency stimulation
- MeSH terms
- Animals, Calcium, Egtazic Acid, Electric Stimulation, Ethylene Glycols, Evoked Potentials, Hippocampus, Membrane Potentials, Time Factors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
