The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.
Open accessAbstract
The purpose of this study was to investigate the induction of inducible nitric oxide synthase (iNOS) mRNA in the brain tissue of rats and mice under the following experimental conditions: in rats infected with borna disease virus and rabies virus, in mice infected with herpes simplex virus, and in rats after the induction of experimental allergic encephalitis. The results showed that iNOS mRNA, normally nondetectable in the brain, was present in animals after viral infection or after induction of experimental allergic encephalitis. The induction of iNOS mRNA coincided with the severity of clinical signs and in some cases with the presence of inflammatory cells in the brain. The results indicate that nitric oxide produced by cells induced by iNOS may be the toxic factor accounting for cell damage and this may open the door to approaches to the study of the pathogenesis of neurological diseases.
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Hibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., & Kushner, J. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115666 · Cited by 485
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
Nussler, A. K., Di Silvio, M., Billiar, T. R., Hoffman, R. A., Geller, D. A., Selby, R., Madariaga, J., & Simmons, R. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.1.261 · Cited by 420
Billiar, T. R., Curran, R. D., Harbrecht, B. G., Stuehr, D. J., Demetris, A. J., & Simmons, R. L. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.48.6.565 · Cited by 335
Cited by
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
Bö, L., Dawson, T. M., Wesselingh, S., Möurk, S., Choi, S., Kong, P. A., Hanley, D., & Trapp, B. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360515 · Cited by 567
Szabó, C., Southan, G. J., & Thiemermann, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12472 · Cited by 406
The cell biology of rabies virus: using stealth to reach the brain
Schnell, M. J., McGettigan, J. P., Wirblich, C., & Papaneri, A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2260 · Cited by 391
Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione
Bolaños, J. P., Heales, S. J. R., Peuchen, S., Barker, J. E., Land, J. M., & Clark, J. B. (1996) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00240-7 · Cited by 263
Role of free radicals in viral pathogenesis and mutation
Akaike, T. (2001) · Reviews in Medical Virology · doi:10.1002/rmv.303 · Cited by 207
Metadata
- Authors
- Koprowski, H., Zheng, Y. M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z. F., Hanlon, C., & Dietzschold, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-04
- Volume
- 90
- Issue
- 7
- Pages
- 3024-3027
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011769338
- Cited by
- 474
- References
- 3
- FWCI
- 21.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Koprowski, H., Zheng, Y. M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z. F., Hanlon, C., & Dietzschold, B. (1993). In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.7.3024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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