The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.
Open accessAbstract
We report two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that belong to the G-protein-associated receptor superfamily. MR22 and REC17 are 371 and 357 amino acids long, respectively, as deduced from nucleotide sequence and share 68% mutual amino acid identity and 30-35% identity with known catecholamine and 5-HT receptors. Saturable binding of 125I-labeled (+)-lysergic acid diethylamide to transiently expressed MR22 in COS-M6 cells was inhibited by ergotamine > methiothepin > 5-carboxamidotryptamine > 5-HT. For REC17, the rank of potency was ergotamine > 5-carboxamidotryptamine > methiothepin > methysergide > 5-HT. Both were insensitive to 5-HT1A, 5-HT1D or 5-HT2 serotonergic ligands [8-hydroxy-2-(di-n-propylamino)tetralin, sumatriptan, and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane]. The mRNAs encoding MR22 were detected in the CA1 region of hippocampus, the medial habenula, and raphe nuclei. In contrast, mRNAs encoding REC17 were found throughout the rat central nervous system. We propose that REC17 and MR22, designated as 5-HT5 alpha and 5-HT5 beta, represent a distinct subfamily of 5-HT receptors.
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Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor
Gall, C. M., & Isackson, P. J. (1989) · Science · doi:10.1126/science.2549634 · Cited by 616
Cited by
Molecular biology of 5-HT receptors
Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462
“On the other hand, the 5-HT5B receptor mRNA is present throughout the rat brain, with higher levels in the hippocampus, hypothalamus, pons, and cortex (Erlander et al., 1993).”
BackgroundMultiplicity of mechanisms of serotonin receptor signal transduction
Raymond, J. R., Mukhin, Y. V., Gelasco, A., Turner, J., Collinsworth, G., Gettys, T. W., Grewal, J. S., & Garnovskaya, M. N. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00169-3 · Cited by 466
The pharmacology of lysergic acid diethylamide: A review
Passie, T., Halpern, J. H., Stichtenoth, D. O., Emrich, H. M., & Hintzen, A. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00059.x · Cited by 455
Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature
Martin, G. R., & Humphrey, P. P. A. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90058-2 · Cited by 305
Metadata
- Authors
- Erlander, M. G., Lovenberg, T. W., Baron, B. M., de Lecea, L., Danielson, P. E., Racke, M., Slone, A. L., Siegel, B. W., Foye, P. E., & Cannon, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-04-15
- Volume
- 90
- Issue
- 8
- Pages
- 3452-3456
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117805673
- Cited by
- 184
- References
- 2
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Erlander, M. G., Lovenberg, T. W., Baron, B. M., de Lecea, L., Danielson, P. E., Racke, M., Slone, A. L., Siegel, B. W., Foye, P. E., & Cannon, K. (1993). Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.8.3452
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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