The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rates of spontaneous mutation among RNA viruses.
Open accessAbstract
Simple methods are presented to estimate rates of spontaneous mutation from mutant frequencies and population parameters in RNA viruses. Published mutant frequencies yield a wide range of mutation rates per genome per replication, mainly because mutational targets have usually been small and, thus, poor samples of the mutability of the average base. Nevertheless, there is a clear central tendency for lytic RNA viruses (bacteriophage Q beta, poliomyelitis, vesicular stomatitis, and influenza A) to display rates of spontaneous mutation of approximately 1 per genome per replication. This rate is some 300-fold higher than previously reported for DNA-based microbes. Lytic RNA viruses thus mutate at a rate close to the maximum value compatible with viability. Retroviruses (spleen necrosis, murine leukemia, Rous sarcoma), however, mutate at an average rate about an order of magnitude lower than lytic RNA viruses.
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Cites
A principle of natural self-organization: Part A: Emergence of the hypercycle
Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752
The accuracy of reverse transcriptase from HIV-1
Roberts, J. D., Bebenek, K., & Kunkel, T. A. (1988) · Science · doi:10.1126/science.2460925 · Cited by 997
Fitness of RNA virus decreased by Muller’s ratchet
Chao, L. (1990) · Nature · doi:10.1038/348454a0 · Cited by 488
Cited by
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Self-citationRNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
Mutation rates among RNA viruses
Drake, J. W., & Holland, J. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13910 · Cited by 1,143
Self-citationRapid Evolution of Pandemic Noroviruses of the GII.4 Lineage
Bull, R. A., Eden, J.-S., Rawlinson, W. D., & White, P. A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000831 · Cited by 301
Theory of lethal mutagenesis for viruses
Bull, J. J., Sanjuán, R., & Wilke, C. O. (2007) · Journal of Virology · doi:10.1128/jvi.01624-06 · Cited by 281
Metadata
- Authors
- Drake, J. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-05
- Volume
- 90
- Issue
- 9
- Pages
- 4171-4175
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053109557
- Cited by
- 712
- References
- 3
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- green
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