The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dynamic instability of microtubules as an efficient way to search in space.
Open accessAbstract
During the formation of the mitotic spindle, dynamic microtubules search for chromosomes in the surrounding cytosol. The average time required to reach such "targets" is calculated within a simple model of dynamic instability. The values of the dynamic parameters that minimize this search time are also obtained. The results approximate well observations of the capture of chromosomes in prometaphase cells. Compared to usual reversible polymerization, dynamic instability reduces the time required to find a target by several orders of magnitude.
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Cites
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Cited by
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 893
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.
Gaglio, T., Saredi, A., Bingham, J. B., Hasbani, M. J., Gill, S. R., Schroer, T. A., & Compton, D. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.2.399 · Cited by 290
Origin and Evolution of the Self-Organizing Cytoskeleton in the Network of Eukaryotic Organelles
Jekely, G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016030 · Cited by 38
Biological processes as exploratory dynamics
Kondev, J., Kirschner, M., Garcia, H. G., Salmon, G. L., & Phillips, R. (2026) · Biophysical Journal · doi:10.1016/j.bpj.2025.09.009 · Cited by 4
Metadata
- Authors
- Holy, T. E., & Leibler, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-06-07
- Volume
- 91
- Issue
- 12
- Pages
- 5682-5685
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2031398978
- Cited by
- 234
- References
- 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
