PreprintCited by 38Microtubule and mitosis dynamicsCellular Mechanics and InteractionsProtist diversity and phylogeny

Origin and Evolution of the Self-Organizing Cytoskeleton in the Network of Eukaryotic Organelles

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Jekely, G.·2014·Cold Spring Harbor Perspectives in Biology

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Abstract

The eukaryotic cytoskeleton evolved from prokaryotic cytomotive filaments. Prokaryotic filament systems show bewildering structural and dynamic complexity and, in many aspects, prefigure the self-organizing properties of the eukaryotic cytoskeleton. Here, the dynamic properties of the prokaryotic and eukaryotic cytoskeleton are compared, and how these relate to function and evolution of organellar networks is discussed. The evolution of new aspects of filament dynamics in eukaryotes, including severing and branching, and the advent of molecular motors converted the eukaryotic cytoskeleton into a self-organizing "active gel," the dynamics of which can only be described with computational models. Advances in modeling and comparative genomics hold promise of a better understanding of the evolution of the self-organizing cytoskeleton in early eukaryotes, and its role in the evolution of novel eukaryotic functions, such as amoeboid motility, mitosis, and ciliary swimming.

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  • Early metazoan cells formed lamellipodia and filopodia, using proteins that reorganize cortical actin filaments such as the Arp2/3 complex, fascin, and myosin X.

    “In addition, we can infer that early metazoan cells formed lamellipodia and filopodia, using proteins that reorganize cortical actin filaments such as the Arp2/3 complex, the actin cross-linking protein fascin, and myosin X”

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Authors
Jekely, G.
Venue
Cold Spring Harbor Perspectives in Biology
Published
2014-09-01
Volume
6
Issue
9
Pages
a016030-a016030
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2168900139
Cited by
38
References
136
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 4
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Funders
  • European Commission (2007–2013, FP7 2007-2013, 260821, FP7/2007)
  • FP7 Ideas: European Research Council (260821)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
Keywords
self-organization, active gels, filament dynamics, molecular motors, amoeboid movement, mitosis, comparative genomics
MeSH terms
Actins, Animals, Cilia, Cytoskeleton, Eukaryotic Cells, Biological Evolution, Fungi, Humans, Microtubules, Mitosis, Spindle Apparatus, Movement, Cluster Analysis, Evolution, Molecular, Molecular Motor Proteins, Eukaryota

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