Origin and Evolution of the Self-Organizing Cytoskeleton in the Network of Eukaryotic Organelles
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Abstract
The eukaryotic cytoskeleton evolved from prokaryotic cytomotive filaments. Prokaryotic filament systems show bewildering structural and dynamic complexity and, in many aspects, prefigure the self-organizing properties of the eukaryotic cytoskeleton. Here, the dynamic properties of the prokaryotic and eukaryotic cytoskeleton are compared, and how these relate to function and evolution of organellar networks is discussed. The evolution of new aspects of filament dynamics in eukaryotes, including severing and branching, and the advent of molecular motors converted the eukaryotic cytoskeleton into a self-organizing "active gel," the dynamics of which can only be described with computational models. Advances in modeling and comparative genomics hold promise of a better understanding of the evolution of the self-organizing cytoskeleton in early eukaryotes, and its role in the evolution of novel eukaryotic functions, such as amoeboid motility, mitosis, and ciliary swimming.
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Early metazoan cells formed lamellipodia and filopodia, using proteins that reorganize cortical actin filaments such as the Arp2/3 complex, fascin, and myosin X.
“In addition, we can infer that early metazoan cells formed lamellipodia and filopodia, using proteins that reorganize cortical actin filaments such as the Arp2/3 complex, the actin cross-linking protein fascin, and myosin X”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [40]
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Cites
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337 · see citing works
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works
Microtubule nucleation by γ-tubulin complexes
Kollman, J. M., Merdes, A., Mourey, L., & Agard, D. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3209 · Cited by 1,583 · see citing works
The Way Things Move: Looking Under the Hood of Molecular Motor Proteins
Vale, R. D., & Milligan, R. A. (2000) · Science · doi:10.1126/science.288.5463.88 · Cited by 1,503 · see citing works
Mullins, R. D., Heuser, J. A., & Pollard, T. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6181 · Cited by 1,496 · see citing works
The energetics of genome complexity.
Lane, N., & Martin, W. (2010) · Nature · doi:10.1038/nature09486 · Cited by 1,289 · see citing works
Classification and evolution of P-loop GTPases and related ATPases
Leipe, D. D., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5378 · Cited by 1,148 · see citing works
The ARP2/3 complex: an actin nucleator comes of age
Goley, E. D., & Welch, M. D. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2026 · Cited by 1,106 · see citing works
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.
Cavalier‐Smith, T. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-2-297 · Cited by 995 · see citing works
Crystal structure of the bacterial cell-division protein FtsZ
Löwe, J., & Amos, L. (1998) · Nature · doi:10.1038/34472 · Cited by 907 · see citing works
Self-organization of microtubules and motors
Ndlec, F. J., Surrey, T., Maggs, A. C., & Leibler, S. (1997) · Nature · doi:10.1038/38532 · Cited by 885 · see citing works
Prokaryotic origin of the actin cytoskeleton
van den Ent, F., Amos, L. A., & Löwe, J. (2001) · Nature · doi:10.1038/35092500 · Cited by 821 · see citing works
Bork, P., Sander, C., & Valencia, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7290 · Cited by 811 · see citing works
Evolutionary history and higher order classification of AAA+ ATPases
Iyer, L. M., Leipe, D. D., Koonin, E. V., & Aravind, L. (2003) · Journal of Structural Biology · doi:10.1016/j.jsb.2003.10.010 · Cited by 782 · see citing works
CLANS: a Java application for visualizing protein families based on pairwise similarity
Frickey, T., & Lupas, A. N. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth444 · Cited by 721 · see citing works
Head to tail polymerization of actin
Wegner, A. (1976) · Journal of Molecular Biology · doi:10.1016/s0022-2836(76)80100-3 · Cited by 716 · see citing works
Tanaka, T. U., Rachidi, N., Janke, C., Pereira, G., Gálová, M., Schiebel, E., Stark, M. J. R., & Nasmyth, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00633-5 · Cited by 714 · see citing works
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
Kapitein, L. C., Peterman, E. J. G., Kwok, B. H., Kim, J. H., Kapoor, T. M., & Schmidt, C. F. (2005) · Nature · doi:10.1038/nature03503 · Cited by 678 · see citing works
The structure of crystalline profilin–β-actin
Schutt, C. E., Myslik, J. C., Rozycki, M. D., Goonesekere, N. C. W., & Lindberg, U. (1993) · Nature · doi:10.1038/365810a0 · Cited by 664 · see citing works
Magnetosomes Are Cell Membrane Invaginations Organized by the Actin-Like Protein MamK
Komeili, A., Li, Z., Newman, D. K., & Jensen, G. J. (2005) · Science · doi:10.1126/science.1123231 · Cited by 647 · see citing works
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
Kull, F. J., Sablin, E. P., Lau, R., Fletterick, R. J., & Vale, R. D. (1996) · Nature · doi:10.1038/380550a0 · Cited by 629 · see citing works
Physical Properties Determining Self-Organization of Motors and Microtubules
Surrey, T., Nédélec, F., Leibler, S., & Karsenti, E. (2001) · Science · doi:10.1126/science.1059758 · Cited by 610 · see citing works
Takenawa, T., & Miki, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1801 · Cited by 604 · see citing works
Processive Movement of MreB-Associated Cell Wall Biosynthetic Complexes in Bacteria
Domínguez‐Escobar, J., Chastanet, A., Crevenna, Á. H., Fromion, V., Wedlich‐Söldner, R., & Carballido‐López, R. (2011) · Science · doi:10.1126/science.1203466 · Cited by 538 · see citing works
Garner, E. C., Bernard, R., Wang, W., Zhuang, X., Rudner, D. Z., & Mitchison, T. J. (2011) · Science · doi:10.1126/science.1203285 · Cited by 526 · see citing works
A Phylogenomic Inventory of Meiotic Genes
Ramesh, M. A., Malik, S.-B., & Logsdon, J. M., Jr. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.003 · Cited by 506 · see citing works
Adaptive evolution of bacterial metabolic networks by horizontal gene transfer
Pál, C., Papp, B., & Lercher, M. J. (2005) · Nature Genetics · doi:10.1038/ng1686 · Cited by 505 · see citing works
A Mechanism for Nuclear Positioning in Fission Yeast Based on Microtubule Pushing
Tran, P. T., Marsh, L., Doye, V., Inoué, S., & Chang, F. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.397 · Cited by 479 · see citing works
Sustained Microtubule Treadmilling in Arabidopsis Cortical Arrays
Shaw, S. L., Kamyar, R. M., & Ehrhardt, D. W. (2003) · Science · doi:10.1126/science.1083529 · Cited by 470 · see citing works
A Processive Single-Headed Motor: Kinesin Superfamily Protein KIF1A
Okada, Y., & Hirokawa, N. (1999) · Science · doi:10.1126/science.283.5405.1152 · Cited by 468 · see citing works
The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility
Fritz‐Laylin, L. K., Prochnik, S. E., Ginger, M. L., Dacks, J. B., Carpenter, M. L., Field, M. C., Kuo, A., Paredez, A. R., Chapman, J., Pham, J. K., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.032 · Cited by 460 · see citing works
Global view of the evolution and diversity of metazoan neuropeptide signaling
Jékely, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221833110 · Cited by 451 · see citing works
Neuwald, A. F. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01034-7 · Cited by 449 · see citing works
Myosin domain evolution and the primary divergence of eukaryotes
Richards, T. A., & Cavalier‐Smith, T. (2005) · Nature · doi:10.1038/nature03949 · Cited by 432 · see citing works
Molecular evolution of peptidergic signaling systems in bilaterians
Mirabeau, O., & Joly, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219956110 · Cited by 423 · see citing works
Powering membrane traffic in endocytosis and recycling
Soldati, T., & Schliwa, M. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2060 · Cited by 378 · see citing works
Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2
Petry, S., Groen, A. C., Ishihara, K., Mitchison, T. J., & Vale, R. D. (2013) · Cell · doi:10.1016/j.cell.2012.12.044 · Cited by 376 · see citing works
Lechtreck, K.-F., Johnson, E. C., Sakai, T., Cochran, D., Ballif, B. A., Rush, J., Pazour, G. J., Ikebe, M., & Witman, G. B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200909183 · Cited by 347 · see citing works
Control of actin assembly and disassembly at filament ends
Cooper, J. A., & Schafer, D. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00062-9 · Cited by 337 · see citing works
A spindle-like apparatus guides bacterial chromosome segregation
Ptacin, J. L., Lee, S. F., Garner, E. C., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2083 · Cited by 335 · see citing works
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation
Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N., & Todokoro, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600347 · Cited by 333 · see citing works
A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps
Bieling, P., Telley, I. A., & Surrey, T. (2010) · Cell · doi:10.1016/j.cell.2010.06.033 · Cited by 326 · see citing works
The evolution of the cytoskeleton
Wickstead, B., & Keith Gull, B. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201102065 · Cited by 318 · see citing works
KIF14 and citron kinase act together to promote efficient cytokinesis
Grüneberg, U., Neef, R., Li, X., Chan, E. H., Chalamalasetty, R. B., Nigg, E. A., & Barr, F. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511061 · Cited by 300 · see citing works
Noree, C., Sato, B. K., Broyer, R. M., & Wilhelm, J. E. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003001 · Cited by 299 · see citing works
Dynamic Instability in a DNA-Segregating Prokaryotic Actin Homolog
Garner, E. C., Campbell, C. S., & Mullins, R. D. (2004) · Science · doi:10.1126/science.1101313 · Cited by 284 · see citing works
Dyneins Across Eukaryotes: A Comparative Genomic Analysis
Wickstead, B., & Gull, K. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00646.x · Cited by 281 · see citing works
Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
Tanenbaum, M. E., Macůrek, L., Janssen, A., Geers, E. F., Álvarez‐Fernández, M., & Medema, R. H. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.027 · Cited by 280 · see citing works
The metabolic enzyme CTP synthase forms cytoskeletal filaments
Ingerson-Mahar, M., Briegel, A., Werner, J. N., Jensen, G. J., & Gitai, Z. (2010) · Nature Cell Biology · doi:10.1038/ncb2087 · Cited by 273 · see citing works
Structural Plasticity in Actin and Tubulin Polymer Dynamics
Kueh, H. Y., & Mitchison, T. J. (2009) · Science · doi:10.1126/science.1168823 · Cited by 270 · see citing works
Bacterial cytokinesis: From Z ring to divisome
Lutkenhaus, J., Pichoff, S., & Du, S. (2012) · Cytoskeleton · doi:10.1002/cm.21054 · Cited by 261 · see citing works
Patronin Regulates the Microtubule Network by Protecting Microtubule Minus Ends
Goodwin, S. S., & Vale, R. D. (2010) · Cell · doi:10.1016/j.cell.2010.09.022 · Cited by 257 · see citing works
The origins of phagocytosis and eukaryogenesis
Yutin, N., Wolf, M. Y., Wolf, Y. I., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-9 · Cited by 247 · see citing works
Crosslinkers and Motors Organize Dynamic Microtubules to Form Stable Bipolar Arrays in Fission Yeast
Janson, M. E., Loughlin, R., Loïodice, I., Fu, C., Brunner, D., Nédélec, F., & Tran, P. T. (2007) · Cell · doi:10.1016/j.cell.2006.12.030 · Cited by 241 · see citing works
Dynamic instability of microtubules as an efficient way to search in space.
Holy, T. E., & Leibler, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5682 · Cited by 238 · see citing works
Xkid, a Chromokinesin Required for Chromosome Alignment on the Metaphase Plate
Antonio, C., Ferby, I., Wilhelm, H., Jones, M., Karsenti, E., Nebreda, Á. R., & Vernos, I. (2000) · Cell · doi:10.1016/s0092-8674(00)00048-9 · Cited by 237 · see citing works
FtsA forms actin‐like protofilaments
Szwedziak, P., Wang, Q., Freund, S. M., & Löwe, J. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.76 · Cited by 233 · see citing works
Evolution of diverse cell division and vesicle formation systems in Archaea
Makarova, K. S., Yutin, N., Bell, S. D., & Koonin, E. V. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2406 · Cited by 228 · see citing works
Jékely, G., & Arendt, D. (2006) · BioEssays · doi:10.1002/bies.20369 · Cited by 221 · see citing works
Excess Membrane Synthesis Drives a Primitive Mode of Cell Proliferation
Mercier, R., Kawai, Y., & Errington, J. (2013) · Cell · doi:10.1016/j.cell.2013.01.043 · Cited by 220 · see citing works
Tubulin‐like protofilaments in Ca2+‐induced FtsZ sheets
Löwe, J., & Amos, L. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2364 · Cited by 220 · see citing works
Reconstitution of DNA Segregation Driven by Assembly of a Prokaryotic Actin Homolog
Garner, E. C., Campbell, C. S., Weibel, D. B., et al. (2007) · Science · doi:10.1126/science.1138527 · Cited by 218 · see citing works
Stepwise evolution of the centriole-assembly pathway
Carvalho-Santos, Z., Machado, P., Branco, P., Tavares-Cadete, F., Rodrigues-Martins, A., Pereira‐Leal, J. B., & Bettencourt‐Dias, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.064931 · Cited by 217 · see citing works
Microtubule-severing enzymes at the cutting edge
Sharp, D. J., & Ross, J. L. (2012) · Journal of Cell Science · doi:10.1242/jcs.101139 · Cited by 214 · see citing works
Assembly and positioning of microtubule asters in microfabricated chambers
Holy, T. E., Dogterom, M., Yurke, B., & Leibler, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6228 · Cited by 211 · see citing works
Computer Simulation of Flagellar Movement
Brokaw, C. J. (1972) · Biophysical Journal · doi:10.1016/s0006-3495(72)86104-6 · Cited by 208 · see citing works
Strauss, M. P., Liew, A. T. F., Turnbull, L., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001389 · Cited by 205 · see citing works
Vater, C. A., Raymond, C. K., Ekena, K., Howald-Stevenson, I., & Stevens, T. H. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.4.773 · Cited by 204 · see citing works
Kim, S. Y., Gitai, Z., Kinkhabwala, A. A., Shapiro, L., & Moerner, W. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604503103 · Cited by 204 · see citing works
Cavalier‐Smith, T. (2012) · European Journal of Protistology · doi:10.1016/j.ejop.2012.06.001 · Cited by 204 · see citing works
Bendezú, F. O., & de Boer, P. A. J. (2007) · Journal of Bacteriology · doi:10.1128/jb.01322-07 · Cited by 200 · see citing works
Computer simulations reveal motor properties generating stable antiparallel microtubule interactions
Nédélec, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202051 · Cited by 195 · see citing works
Curved FtsZ protofilaments generate bending forces on liposome membranes
Osawa, M., Anderson, D. E., & Erickson, H. P. (2009) · EMBO Journal · doi:10.1038/emboj.2009.277 · Cited by 180 · see citing works
Larsen, R. A., Cusumano, C., Fujioka, A., Lim‐Fong, G., Patterson, P., & Pogliano, J. (2007) · Genes & Development · doi:10.1101/gad.1546107 · Cited by 180 · see citing works
Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter
Jenkins, C., Samudrala, R., Anderson, I., Hedlund, B. P., Petroni, G., Michailova, N., Pinel, N., Overbeek, R., Rosati, G., & Staley, J. T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012516899 · Cited by 179 · see citing works
Failure of a single-headed kinesin to track parallel to microtubule protofilaments
Berliner, E., Young, E. C., Anderson, K., Mahtani, H. K., & Gelles, J. (1995) · Nature · doi:10.1038/373718a0 · Cited by 174 · see citing works
Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity
Suryavanshi, S., Eddé, B., Fox, L. A., Guerrero, S., Hard, R., Hennessey, T. M., Kabi, A., Malison, D., Pennock, D. G., Sale, W. S., et al. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.062 · Cited by 169 · see citing works
Structure of bacterial tubulin BtubA/B: Evidence for horizontal gene transfer
Schlieper, D., Oliva, M. A., Andreu, J. M., & Löwe, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502859102 · Cited by 167 · see citing works
An actin‐based cytoskeleton in archaea
Ettema, T. J. G., Lindås, A., & Bernander, R. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07635.x · Cited by 166 · see citing works
Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the wild-type gene.
Mitchell, D. R., & Kang, Y. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.4.835 · Cited by 152 · see citing works
KIF19A Is a Microtubule-Depolymerizing Kinesin for Ciliary Length Control
Niwa, S., Nakajima, K., Miki, H., Minato, Y., Wang, D., & Hirokawa, N. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.016 · Cited by 151 · see citing works
A Rapid Fluorescence Assay for FtsZ Assembly Indicates Cooperative Assembly with a Dimer Nucleus
Chen, Y., Bjornson, K. P., Redick, S. D., et al. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.044149 · Cited by 146 · see citing works
Actin-like cytoskeleton filaments contribute to cell mechanics in bacteria
Wang, S. S., Arellano-Santoyo, H., Combs, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911517107 · Cited by 145 · see citing works
Wickstead, B., Gull, K., & Richards, T. A. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-110 · Cited by 142 · see citing works
Small GTPases and the evolution of the eukaryotic cell
Jékely, G. (2003) · BioEssays · doi:10.1002/bies.10353 · Cited by 137 · see citing works
Fenton, A. K., & Gerdes, K. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.129 · Cited by 136 · see citing works
Evolution of cytomotive filaments: The cytoskeleton from prokaryotes to eukaryotes
Löwe, J., & Amos, L. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.010 · Cited by 135 · see citing works
Bacterial DNA segregation by dynamic SopA polymers
Lim, G. E., Derman, A. I., & Pogliano, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507222102 · Cited by 131 · see citing works
Directed cytoskeleton self-organization
Vignaud, T., Blanchoin, L., & Théry, M. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.012 · Cited by 131 · see citing works
Pilhofer, M., Ladinsky, M. S., McDowall, A. W., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001213 · Cited by 131 · see citing works
A Tight Link between Orthologs and Bidirectional Best Hits in Bacterial and Archaeal Genomes
Wolf, Y. I., & Koonin, E. V. (2012) · Genome Biology and Evolution · doi:10.1093/gbe/evs100 · Cited by 130 · see citing works
Self-organisation and forces in the microtubule cytoskeleton
Nédélec, F., Surrey, T., & Karsenti, E. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00014-5 · Cited by 129 · see citing works
Getting organized — how bacterial cells move proteins and DNA
Thanbichler, M. R., & Shapiro, L. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1795 · Cited by 129 · see citing works
Takada, S., & Kamiya, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.3.737 · Cited by 129 · see citing works
Regulation of dynamic polarity switching in bacteria by a Ras‐like G‐protein and its cognate GAP
Leonardy, S., Miertzschke, M., Bulyha, I., Sperling, E., Wittinghofer, A., & Søgaard‐Andersen, L. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.114 · Cited by 125 · see citing works
Chapter 3 How Did the Cilium Evolve?
Satir, P., Mitchell, D. R., & Jékely, G. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00803-x · Cited by 123 · see citing works
Derman, A. I., Becker, E. C., Truong, B. D., Fujioka, A., Tucey, T. M., Erb, M. L., Patterson, P., & Pogliano, J. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06771.x · Cited by 123 · see citing works
Microtubule tip-interacting proteins: a view from both ends
Jiang, K., & Akhmanova, A. S. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.008 · Cited by 121 · see citing works
Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II
Fang, X., Luo, J., Nishihama, R., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005134 · Cited by 121 · see citing works
Speculations on the evolution of 9+2 organelles and the role of central pair microtubules
Mitchell, D. R. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.07.004 · Cited by 107 · see citing works
The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape
Tollis, S., Dart, A., Tzircotis, G., & Endres, R. G. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-149 · Cited by 103 · see citing works
Yutin, N., & Koonin, E. V. (2012) · Biology Direct · doi:10.1186/1745-6150-7-10 · Cited by 100 · see citing works
A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation
Gayathri, P., Fujii, T., Møller‐Jensen, J., et al. (2012) · Science · doi:10.1126/science.1229091 · Cited by 95 · see citing works
Modelling microtubule patterns
Karsenti, E., Nédélec, F., & Surrey, T. (2006) · Nature Cell Biology · doi:10.1038/ncb1498 · Cited by 92 · see citing works
The diversity of forms of mitosis in protozoa: a comparative review
Raikov, I. B. (1994) · European Journal of Protistology · doi:10.1016/s0932-4739(11)80072-6 · Cited by 90 · see citing works
Tubulin depolymerization may be an ancient biological motor
McIntosh, J. R., Volkov, V. A., Ataullakhanov, F. I., & Grishchuk, E. L. (2010) · Journal of Cell Science · doi:10.1242/jcs.067611 · Cited by 87 · see citing works
Filament structure of bacterial tubulin homologue TubZ
Aylett, C. H. S., Wang, Q. K., Michie, K. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010176107 · Cited by 81 · see citing works
The FtsH Protein Accumulates at the Septum of Bacillus subtilis during Cell Division and Sporulation
Wehrl, W., Niederweis, M., & Schumann, W. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.13.3870-3873.2000 · Cited by 75 · see citing works
Chalkia, D., Nikolaidis, N., Makałowski, W., Klein, J., & Nei, M. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn215 · Cited by 72 · see citing works
Eckert, C., Hammesfahr, B., & Kollmar, M. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-268 · Cited by 68 · see citing works
Brokaw, C. J. (2004) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20046 · Cited by 68 · see citing works
Filament Structure, Organization, and Dynamics in MreB Sheets
Popp, D., Narita, A., Maéda, K., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095901 · Cited by 67 · see citing works
The bacterial cytoskeleton: more than twisted filaments
Pilhofer, M., & Jensen, G. J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.019 · Cited by 58 · see citing works
Kinesin 9 family members perform separate functions in the trypanosome flagellum
Demonchy, R., Blisnick, T., Deprez, C., Toutirais, G., Loussert-Fonta, C., Marande, W., Grellier, P., Bastin, P., & Kohl, L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200903139 · Cited by 58 · see citing works
Bacterial actin: architecture of the ParMRC plasmid DNA partitioning complex
Salje, J., & Löwe, J. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.152 · Cited by 58 · see citing works
EGN: a wizard for construction of gene and genome similarity networks
Halary, S., McInerney, J. O., Lopez, P., & Bapteste, E. P. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-146 · Cited by 56 · see citing works
Chromosome segregation in Archaea mediated by a hybrid DNA partition machine
Kalliomaa-Sanford, A. K., Rodríguez-Castañeda, F., McLeod, B. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113384109 · Cited by 54 · see citing works
Self-assembling enzymes and the origins of the cytoskeleton
Barry, R. M., & Gitai, Z. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.09.015 · Cited by 52 · see citing works
Atomic resolution structure of human α-tubulin acetyltransferase bound to acetyl-CoA
Taschner, M. J., Vetter, M., & Lorentzen, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209343109 · Cited by 47 · see citing works
Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein
Hammesfahr, B., & Kollmar, M. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-95 · Cited by 43 · see citing works
Gandhi, S. R., Gierliński, M., Mino, A., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.006 · Cited by 42 · see citing works
Suprastructures and Dynamic Properties of Mycobacterium tuberculosis FtsZ
Popp, D., Iwasa, M., Erickson, H., Narita, A., Maéda, Y., & Robinson, R. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.084079 · Cited by 41 · see citing works
Nédélec, F. (2002) · arXiv (Cornell University) · doi:10.17863/cam.55697 · Cited by 35 · see citing works
Polymeric Structures and Dynamic Properties of the Bacterial Actin AlfA
Popp, D., Narita, A., Ghoshdastider, U., et al. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.02.010 · Cited by 34 · see citing works
Alternative cytoskeletal landscapes: cytoskeletal novelty and evolution in basal excavate protists
Dawson, S. C., & Paredez, A. R. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.11.005 · Cited by 34 · see citing works
An archaeal origin for the actin cytoskeleton: Implications for eukaryogenesis
Bernander, R., Lind, A. E., & Ettema, T. J. G. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.16974 · Cited by 33 · see citing works
Jékely, G. (2008) · Biology Direct · doi:10.1186/1745-6150-3-31 · Cited by 31 · see citing works
Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms.
Jékely, G. (2007) · Biology Direct · doi:10.1186/1745-6150-2-3 · Cited by 27 · see citing works
Winston, S. (1978) · Cited by 26 · see citing works
A Complex Cell Division Machinery Was Present in the Last Common Ancestor of Eukaryotes
Eme, L., Moreira, D., Talla, E., & Brochier‐Armanet, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005021 · Cited by 25 · see citing works
Origins and Evolution of the Actin Cytoskeleton
Rivero, F., & Cvrčková, F. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74021-8_8 · Cited by 23 · see citing works
Eukaryotic Domain of Unknown Function DUF738 Belongs to Gcn5-related N-acetyltransferase Superfamily
Steczkiewicz, K., Kinch, L. N., Grishin, N. V., et al. (2006) · Cell Cycle · doi:10.4161/cc.5.24.3572 · Cited by 20 · see citing works
Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH
Gopalakrishnapillai, A., Srinivasan, R., Anand, S. P., et al. (2001) · Microbiology · doi:10.1099/00221287-147-3-516 · Cited by 20 · see citing works
Dynamic instability-driven centering/segregating mechanism in bacteria
Drew, K. R. P., & Pogliano, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018724108 · Cited by 19 · see citing works
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
Kull, F. J., Sablin, E. P., Lau, R., et al. (1996) · Acta Crystallographica Section A Foundations of Crystallography · doi:10.1107/s0108767396090939 · Cited by 16 · see citing works
Microtubule-like Properties of the Bacterial Actin Homolog ParM-R1
Popp, D., Narita, A., Lee, L. J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.319491 · Cited by 5 · see citing works
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The Syntrophy hypothesis for the origin of eukaryotes revisited
López-García, P., & Moreira, D. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0710-4 · Cited by 201 · see citing works
Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution
Arendt, D., Benito-Gutierrez, E., Brunet, T., & Marlow, H. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0286 · Cited by 112 · see citing works
- Authors
- Jekely, G.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-09-01
- Volume
- 6
- Issue
- 9
- Pages
- a016030-a016030
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4142967
- OpenAlex
- W2168900139
- Cited by
- 38
- References
- 136
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Funders
- European Commission (2007–2013, FP7 2007-2013, 260821, FP7/2007)
- FP7 Ideas: European Research Council (260821)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Keywords
- self-organization, active gels, filament dynamics, molecular motors, amoeboid movement, mitosis, comparative genomics
- MeSH terms
- Actins, Animals, Cilia, Cytoskeleton, Eukaryotic Cells, Biological Evolution, Fungi, Humans, Microtubules, Mitosis, Spindle Apparatus, Movement, Cluster Analysis, Evolution, Molecular, Molecular Motor Proteins, Eukaryota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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