The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.
Open accessAbstract
We have studied the ability of c-myc and bcl-2 oncogenes to modulate p53 function. Our studies show that coincident expression of human Bcl-2 protein with p53 prolongs survival of murine erythroleukemia cells. This effect was associated with a loss of the G1 specificity of p53-mediated cell cycle arrest. Furthermore, we found that the c-myc and bcl-2 genes cooperate to inhibit p53 functions. Coexpression of bcl-2 and c-myc can totally overcome p53-induced apoptosis and cell cycle arrest by altering the subcellular trafficking of p53 during the cell cycle: the p53 remains in the cytoplasm of the cotransfected cells during a critical period in G1. This finding suggests a mechanism by which normal hematopoietic progenitors can survive and proliferate despite p53 expression and by which the inappropriate expression of bcl-2 and c-myc can cooperate in transformation.
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Citations
Cites
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Metadata
- Authors
- Ryan, J. J., Prochownik, E., Gottlieb, C. A., Apel, I. J., Merino, R., Nuñez, G., & Clarke, M. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-06-21
- Volume
- 91
- Issue
- 13
- Pages
- 5878-5882
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973073454
- Cited by
- 207
- References
- 3
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Ryan, J. J., Prochownik, E., Gottlieb, C. A., Apel, I. J., Merino, R., Nuñez, G., & Clarke, M. F. (1994). c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.13.5878
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
